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300115S

Avanti

Dox-NP™ (5mL vial)

Avanti Research™ - A Croda Brand

Synonym(s):

Dox-NP™ (5mL vial)

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.25

description

Dox-NP™ (Liposomal Encapsulated Doxorubicin)
frozen liposomal suspension (buffer - 10% w/w sucrose, 10 mM histidine ~pH 6.5)

Assay

>99% (HPLC/MS)

form

dispersion

packaging

pkg of 1 × 5 mL (300115S-1EA)

manufacturer/tradename

Avanti Research™ - A Croda Brand

application(s)

advanced drug delivery

shipped in

dry ice

storage temp.

−20°C

General description

Formulation: A Pegylated, long-circulating liposomal formulation with doxorubicin entrapped within an ammonium sulfate core via remote-loading. All unencapsulated was removed to yield a completely liposomal doxorubicin product. Liposomes are stored frozen for a longer shelf life.

Application

Dox-NP™(5mL vial) has been used as a sample to study its characteristics by asymmetrical-flow field flow fractionation (MD-AF4). It may also be used as an intravenous (i.v.) injection in flank or orthotopic animal models of cancer.

Packaging

10 mL amber serum vial (300115S-1EA)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
Dox-NP is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Physical characterization of liposomal drug formulations using multi-detector asymmetrical-flow field flow fractionation
Parot J, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society (2020)
J Parot et al.
Journal of controlled release : official journal of the Controlled Release Society, 320, 495-510 (2020-02-01)
Liposomal formulations for the treatment of cancer and other diseases are the most common form of nanotechnology enabled pharmaceuticals (NEPs) submitted for market approval and in clinical application today. The accurate characterization of their physical-chemical properties is a key requirement;

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