Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

725765

Sigma-Aldrich

2-Methyl-4-isothiazolin-3-one

95%

Synonym(s):

2-Methyl-3(2H)-isothiazolone

Sign Into View Organizational & Contract Pricing

Select a Size

5 G
NOK 684.00
25 G
NOK 2,560.00

NOK 684.00

Please contact Customer Service for Availability
Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 G
NOK 684.00
25 G
NOK 2,560.00

About This Item

Empirical Formula (Hill Notation):
C4H5NOS
CAS Number:
2682-20-4
Molecular Weight:
115.15
Beilstein:
606203
EC Number:
220-239-6
MDL number:
MFCD01742315
UNSPSC Code:
12352100
PubChem Substance ID:
329764182
NACRES:
NA.21

NOK 684.00

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

100

Assay

≥94.0% (GC)
95%

form

lumps

impurities

≤5% water

SMILES string

CN1SC=CC1=O

InChI

1S/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3

InChI key

BEGLCMHJXHIJLR-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

  • Insights into the mechanisms of within-species variation in sensitivity to chemicals: A case study using daphnids exposed to CMIT/MIT biocide.: This study investigates the differential sensitivity of daphnids to 2-Methyl-4-isothiazolin-3-one, highlighting the biochemical mechanisms underlying these variations. The findings provide crucial insights for environmental safety assessments (Kim et al., 2023).
  • Effects of the biocide methylisothiazolinone on Xenopus laevis wound healing and tail regeneration.: The study assesses the impact of 2-Methyl-4-isothiazolin-3-one on regenerative processes in amphibians, contributing to the understanding of its biological effects and potential toxicity (Delos Santos et al., 2016).
  • T cell lymphomatoid contact dermatitis: a challenging case and review of the literature.: This review includes discussions on 2-Methyl-4-isothiazolin-3-one-induced contact dermatitis, providing valuable information for dermatological applications and safety assessments (Knackstedt and Zug, 2015).

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A

Supplementary Hazards

EUH071

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCM7270
BCCG6210
BCCM6941
BCCL7663
BCCM0911

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A Spawn et al.
Neuroscience, 205, 194-204 (2012-01-17)
Methylisothiazolinone (MIT) is a commonly used biocide known to be neurotoxic in vitro. Brief exposure of cortical neurons in culture to MIT results in increased neurodegeneration, whereas chronic exposure of developing neurons in culture to low concentrations of MIT has
Christina L Burnett et al.
International journal of toxicology, 29(4 Suppl), 187S-213S (2010-07-22)
Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble
Johannes Geier et al.
Contact dermatitis, 67(6), 334-341 (2012-09-22)
The frequency of sensitization to methylchloroisothiazolinone (MCI)/ methylisothiazolinone (MI) observed in the Information Network of Departments of Dermatology (IVDK) was constantly around 2.1% from 1998 to 2009. After that, it increased to 3.9% in 2011, paralleled by an increase in
Wolfgang Uter et al.
Contact dermatitis, 67(3), 125-129 (2012-05-09)
The preservative methylchloroisothiazolinone (MCI)/methylisothiazo- linone (MI) is an important allergen, and has thus been subject to regulation in some areas of exposure, mainly in cosmetics. To examine whether a decline in sensitization prevalence and intensity of elicitation (by the patch
Juan García-Gavín et al.
Contact dermatitis, 63(2), 96-101 (2010-07-16)
A few cases on primary sensitization by, and occupational contact dermatitis from, methylisothiazolinone in paints and glues have been published. In cosmetics, methylisothiazoline (MI) is permitted in a concentration of 100 p.p.m., while 15 p.p.m. for the mixture of methylchloroisothiazolinone
View All Related Papers

Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. Is there a liquid version available for part # 725765?

    1 answer

    1. Presently, a liquid form of this product is not available. The appearance is validated for each batch release, and batches with high purity consistently exist in solid form. However, this product may also be released with a purity of 95%, where the presence of other substances, such as water, might cause the product to appear in a liquid, semi-solid, or paste form.

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service