706574

N-Boc-cis-4-hydroxy-D-proline

97%

• Synonym(s): (2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecarboxylic acid
• Empirical Formula (Hill Notation): C₁₀H₁₇NO₅
• CAS Number: 135042-12-5
• Molecular Weight: 231.25
• MDL number: MFCD02094407
• UNSPSC Code: 12352005
• eCl@ss: 32160406
• PubChem Substance ID: 329762652
• NACRES: NA.22

Properties

• Assay: 97%
• form: solid
• optical activity: [α]22/D +50.0°, c = 1 in methanol
• mp: 146-151 °C
• application(s): peptide synthesis
• storage temp.: 2-8°C
• SMILES string: CC(C)(C)OC(=O)N1C[C@H](O)C[C@@H]1C(O)=O
• InChI: 1S/C10H17NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7-/m1/s1
• InChI key: BENKAPCDIOILGV-RNFRBKRXSA-N

Description

Application

N-Boc-cis-4-hydroxy-D-proline can be used:

• As a starting material in the synthesis of DNA mimicking pyrrolidine peptide nucleic acid (PNA) analog.
• In the synthesis of biologically important macrocyclic dilactones.
• As an intermediate in the synthesis of histamine H₃ receptor antagonists.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable