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Sigma-Aldrich

Poly(ethylene glycol) diglycidyl ether

average MN 500, cross-linking reagent amine reactive, glycidyl

Synonym(s):

Polyethylene glycol, Diepoxy PEG, PEG diglycidyl ether, Polyoxyethylene bis(glycidyl ether)

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About This Item

Linear Formula:
C3H5O2-(C2H4O)n-C3H5O
CAS Number:
26403-72-5
UNSPSC Code:
12162002
NACRES:
NA.23

product name

Poly(ethylene glycol) diglycidyl ether, average Mn 500

mol wt

average Mn 500

reaction suitability

reagent type: cross-linking reagent
reactivity: amine reactive

refractive index

n20/D 1.47

Ω-end

epoxy

α-end

epoxy

polymer architecture

shape: linear
functionality: homobifunctional

storage temp.

2-8°C

InChI

1S/C8H14O4/c1(9-3-7-5-11-7)2-10-4-8-6-12-8/h7-8H,1-6H2

InChI key

AOBIOSPNXBMOAT-UHFFFAOYSA-N

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General description

Poly(ethylene glycol) diglycidyl ether (PEGDGE) shows highly solubility in water. Hence, it easily undergoes hydrolysis followed by ring cleavage reaction in aqueous solution, yielding hydroxyl group. PEGDGE combines with proteins covalently or non-covalently. PEGDGE is widely used in chemical industries for cross linking and surface modifier.

Application

The high solubility of PEGDGE has been successfully employed to immobilize glucose oxidase, d-amino acid oxidase and glutamate oxidase. It may be used as a component for the development of microelectrode biosensors to detect hydrogen peroxide and nitric oxide.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

386.6 °F - closed cup

Flash Point(C)

197.00 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Direct electrochemistry and electrocatalysis of hemoglobin on a glassy carbon electrode modified with poly (ethylene glycol diglycidyl ether) and gold nanoparticles on a quaternized cellulose support. A sensor for hydrogen peroxide and nitric oxide.
Li F,et al.
Microchimica Acta, 1-9 (2014)
High performance organic solvent nanofiltration membranes: Development and thorough testing of thin film composite membranes made of polymers of intrinsic microporosity (PIMs)
Fritsch D, et al.
Journal of Membrane Science, 401, 222-231 (2012)
Dilu G Mathew et al.
Nano letters, 20(2), 820-828 (2019-09-20)
Tumor-derived extracellular vesicles (tdEVs) are attracting much attention due to their essential function in intercellular communication and their potential as cancer biomarkers. Although tdEVs are significantly more abundant in blood than other cancer biomarkers, their concentration compared to other blood
Oylum Colpankan Gunes et al.
Journal of biomaterials applications, 35(4-5), 515-531 (2020-07-01)
The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix. In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel

Articles

Patterning PEG-based Hydrogels for Complexity

Scaffold patterning with poly(ethylene glycol)-based hydrogels for cell presence in 2D and 3D environments on photoactive substrates.

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds: Bio-orthogonal Click

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

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