569251-U
Discovery® HS C18 (3 µm) HPLC Columns
L × I.D. 7.5 cm × 4.6 mm, HPLC Column
Synonym(s):
Discovery RP18 HPLC Column
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About This Item
UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
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product name
Discovery® HS C18 HPLC Column, 3 μm particle size, L × I.D. 7.5 cm × 4.6 mm
material
stainless steel column
Agency
suitable for USP L1
product line
Discovery®
feature
endcapped
manufacturer/tradename
Discovery®
packaging
1 ea of
extent of labeling
20% Carbon loading
parameter
≤70 °C temp. range
400 bar pressure (5801 psi)
technique(s)
HPLC: suitable
LC/MS: suitable
L × I.D.
7.5 cm × 4.6 mm
surface area
300 m2/g
surface coverage
3.2 μmol/m2
impurities
<10 ppm metals
matrix
silica gel, high purity, spherical particle platform
fully porous particle
matrix active group
C18 (octadecyl) phase
particle size
3 μm
pore size
120 Å
operating pH range
2-8
application(s)
food and beverages
separation technique
reversed phase
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General description
Discovery® HS C18 HPLC column (L × I.D. 7.5 cm × 4.6 mm) is generally found to be stable under acidic and basic conditions.
Application
- A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies.: This research demonstrates the use of the Discovery® HS C18 HPLC Column in developing a robust HPLC method for analyzing molnupiravir, showcasing its importance in current pandemic-related pharmaceutical research (Recber et al., 2022).
- A new RP-HPLC method as an auxiliary tool for optimization of sample preparation procedures for tracing of PPCPs of different hydrophilicities.: Highlights the adaptability of the Discovery® HS C18 HPLC Column in environmental monitoring, specifically for pharmaceutical and personal care products, enhancing analytical methods for environmental safety (Portillo-Castillo et al., 2021).
- Analysis of terizidone in plasma using HPLC-UV method and its application in a pharmacokinetic study of patients with drug-resistant tuberculosis.: This study uses the Discovery® HS C18 HPLC Column to assess terizidone levels in patient plasma, providing critical insights into the treatment of drug-resistant tuberculosis (Mulubwa and Mugabo, 2018).
- Optimization of LC method for the quantification of doxorubicin in plasma and urine samples in view of pharmacokinetic, biomedical and drug monitoring therapy studies.: Depicts the utility of the Discovery® HS C18 HPLC Column in optimizing liquid chromatography methods for the potent chemotherapeutic agent doxorubicin, underscoring its role in therapeutic drug monitoring (Maliszewska et al., 2018).
- Universal efavirenz determination in transport study, rat placenta perfusion and placenta lysate by HPLC-UV.: Showcases the Discovery® HS C18 HPLC Column′s application in studying the permeability and transport of efavirenz across the placenta, providing valuable pharmacological insights (Zelena et al., 2017).
Features and Benefits
- Stable, low bleed for LC-MS applications
- Scalable from analytical to preparatory
- Highly stable to ensure excellent run-to-run and lot-to-lot reproducibility
- Higher hydrophobicity for better resolution of difficult analytes
Legal Information
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
guard cartridge
Product No.
Description
Pricing
related product
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Jolanta Flieger et al.
Journal of separation science, 34(7), 733-739 (2011-03-02)
Highly hydrophilic compounds belonging to biogenic amines were analysed in the reversed-phase system, modified with the addition of ionic liquids: 1-ethyl-3-methyl-imidazolium hexafluorophosphate (EMIM PF(6)) and chaotropic salt NaPF(6) on Discovery HS C18 column at acidic conditions. The effect of the
Swati Jaiswal et al.
Journal of chromatographic science, 55(6), 617-624 (2017-03-24)
Tuberculosis (TB) with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome represents the most common infectious diseases worldwide. Anti-TB drugs are used concurrently with antiretroviral drug for treatment of TB-HIV co-morbidities. Due to lower risk of interaction with protease inhibitors, rifabutin is
Abad Khan et al.
Talanta, 84(3), 789-801 (2011-04-13)
A new, simple, economical and validated high-performance liquid chromatography linked with electrochemical detector (HPLC-ECD) method has been developed and optimized for different experimental parameters to analyze the most common monothiols and disulfide (cystine, cysteine, homocysteine, methionine, reduced (GSH) and oxidized
Bhavin N Patel et al.
Biomedical chromatography : BMC, 22(11), 1213-1224 (2008-07-25)
A simple, precise and accurate assay for the determination of 6-methoxy-2-naphthylacetic acid (6-MNA), an active metabolite of nabumetone in human plasma, was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The analyte (6-MNA) and propranolol (internal standard, IS) were
Lucie Zelena et al.
Journal of pharmaceutical and biomedical analysis, 137, 70-77 (2017-01-17)
Efavirenz is an antiretroviral drug used in the treatment of HIV-positive patients. A simple, fast and sensitive high-performance liquid chromatography (HPLC) method was developed in order to determine efavirenz in three types of samples provided from pharmacokinetic studies. The analysis
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HPLC DiscoveryBIO HS C18 products. Available in 3µm, 5µm and 10µm particle sizes.
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