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T3126

Sigma-Aldrich

D-α-Tocopherol succinate

semisynthetic, 1210 IU/g

Synonym(s):

Vitamin E succinate

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About This Item

Empirical Formula (Hill Notation):
C33H54O5
CAS Number:
4345-03-3
Molecular Weight:
530.78
Beilstein:
4038233
EC Number:
224-403-8
MDL number:
MFCD00072055
UNSPSC Code:
12352205
eCl@ss:
34058016
PubChem Substance ID:
24900107
NACRES:
NA.28

biological source

semisynthetic

form

powder

specific activity

1210 IU/g

color

white to yellow

storage temp.

room temp

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)CCC(O)=O)c(C)c(C)c2O1

InChI

1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1

InChI key

IELOKBJPULMYRW-NJQVLOCASA-N

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General description

α-Tocopherol succinate is a fat soluble vitamin. α-Tocopherol is a form of vitamin E, which can be obtained through dietary sources. RRR-α-tocopherol is a natural form of α-Tocopherol.

Application

D-α-Tocopherol succinate has been used:
  • to as a dietary supplement to study its immunomodulatory effects in chicks
  • as a dietary supplement in pregnant women to evaluate its effects on arsenic exposure
  • as an antioxidant to investigate concurrent pathways of cell death due to acute exercise

Biochem/physiol Actions

α-Tocopherol is also called as a radical-chain breaker due to its anti-oxidant property.
Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. α-Tocopherol succinate is used along the α-Tocopherol acetate, α-Tocopherol nicotinate and other esterified forms as a vitamin E supplement with similar but differential activities.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Effects of immunomodulatory nutrients on growth performance and immune-related gene expression in layer chicks challenged with lipopolysaccharide
Wils-Plotz EL and Klasing KC
Poultry Science, 96(3), 548-555 (2017)
Maria F Arisi et al.
Physiological reports, 5(11) (2017-06-04)
Aerobic exercise confers many health benefits. However, numerous reports have shown that acute aerobic exercise can injure the heart. We tested the general hypothesis that acute moderate-intensity exercise in rodents induces cardiomyocyte damage and stimulates mesenchymal stem cells (MSCs) to
Wenbin Zhu et al.
PloS one, 9(3), e92992-e92992 (2014-03-26)
Benzo[a]pyrene (BaP), a well-known environmental carcinogen, promotes oxidative stress and DNA damage. Curcumin and vitamin E (VE) have potent antioxidative activity that protects cells from oxidative stress and cellular damage. The objectives of the present study were to investigate the
Tocopherols, tocotrienols and tocomonoenols: Many similar molecules but only one vitamin E
Azzi A
Redox Biology, 101259-101259 (2019)
Pankaj K Singh et al.
Cytokine, 56(2), 411-421 (2011-09-02)
The purpose of this study was to elucidate the role of granulocyte colony-stimulating factor (G-CSF) induced by α-tocopherol succinate (TS) in protecting mice from total-body irradiation. CD2F1 mice were injected with a radioprotective dose of TS and the levels of
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Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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