SAB4300830

Anti-UCN antibody produced in rabbit

affinity isolated antibody

• Synonym(s): UI, UROC
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat, human, mouse
• concentration: 0.7 mg/mL
• technique(s): immunohistochemistry: 1:25- 1:100
• isotype: IgG
• accession no.: NP_003344.1
• UniProt accession no.: P55089
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... UCN(7349)

Description

General description

Urocortin (UCN) belongs to the hypothalamic hormone corticotrophin-releasing factor (CRF) family. UCN has 45% homology to CRF. UCN is expressed in brain, placenta, lymphocytes and heart. In human chromosome, the gene UCN is localized on 2p23.3.

Specificity

The antibody detects endogenous levels of total UCN protein.

Immunogen

Synthetic peptide corresponding to residues near the C terminal of human urocortin

Application

Anti-UCN antibody produced in rabbit has been used in immunohistochemical analysis.

Biochem/physiol Actions

Urocortin (UCN1) is a key protein involved in regulating hypothalamic-pituitary-adrenal axis and modulating stress responses. Ucn1 is associated with both G-protein coupled CRF receptors and CRF binding proteins. UCN increases the heart rate, cardiac output, and coronary blood flow according to the dosage. UCN protects cardiac myocytes from cell death due to stress. Ucn upregulates p42/p44 mitogen activated protein kinase (MAPK) signalling pathway and protects the heart from reperfusion injury. High levels of Ucn mRNA have been observed in the Edinger−Westphal (EW) nucleus, associated with alcohol and drug addiction. Ucn delays the gastric emptying and reduces the food intake and thus regulates the body weight. Ucn enhances anxiogenic-like or stress-like effect. Ucn causes degranulation of mast cells and increases vascular permeability in response to stress. Ucn is found to be associated with stress induced atopic dermatitis or psoriasis.

Features and Benefits

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Physical form

Rabbit IgG in pH7.3 PBS, 0.05% NaN₃, 50% Glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable