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Key Documents

SAB4300102

Sigma-Aldrich

Anti-phospho-AKT2 (pSer474) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-PKBB antibody produced in rabbit, Anti-PKBBETA antibody produced in rabbit, Anti-PRKBB antibody produced in rabbit, Anti-RAC-BETA antibody produced in rabbit, Anti-v-akt murine thymoma viral oncogene homolog 2 antibody produced in rabbit

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About This Item

MDL number:
MFCD01633020
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~60 kDa

species reactivity

human, rat, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(Q-F-SP-Y-S)

NCBI accession no.

NP_001617.1

UniProt accession no.

P31751

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer474)

Gene Information

human ... AKT2(208)

Immunogen

Peptide sequence around phosphorylation site of serine 474 (Q-F-S(p)-Y-S), according to the protein AKT2.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

General protein kinase capable of phosphorylating several known proteins.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alberto Bavelloni et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(8), 9044-9061 (2019-05-17)
Murine thymoma viral oncogene homolog (AKT) kinases target both cytosolic and nuclear substrates for phosphorylation. Whereas the cytosolic substrates are known to be closely associated with the regulation of apoptosis and autophagy or metabolism and protein synthesis, the nuclear substrates
Daolu Yuwen et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 28(1), 163-173 (2018-09-20)
Platinum-based doublets with a third-generation agent are the recommended option for many patients with non-small cell lung cancer (NSCLC) with no contraindications to platinum compounds. Unfortunately, the clinical effectiveness of such chemotherapy is limited by intrinsic or acquired resistance. Circulating
K Soukupová et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 52, 58-67 (2019-02-09)
The specific effects of sodium selenite (selenite) on a chemoresistant human bladder cancer cell line RT-112/D21 were investigated during 72 h. Selenite at low concentration of 2.5 μmol (otherwise tolerated in normal urothelial cells UROtsa) suppressed growth and proliferation of the tested

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