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S4570

Sigma-Aldrich

Sulochrin

≥98% (HPLC), solid

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About This Item

Empirical Formula (Hill Notation):
C17H16O7
CAS Number:
519-57-3
Molecular Weight:
332.30
MDL number:
MFCD07370145
UNSPSC Code:
51111800
PubChem Substance ID:
24899610

Assay

≥98% (HPLC)

form

solid

solubility

DMF: soluble
DMSO: soluble
ethanol: soluble
methanol: soluble

antibiotic activity spectrum

fungi

Mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

COC(=O)c1cc(O)cc(OC)c1C(=O)c2c(O)cc(C)cc2O

InChI

1S/C17H16O7/c1-8-4-11(19)15(12(20)5-8)16(21)14-10(17(22)24-3)6-9(18)7-13(14)23-2/h4-7,18-20H,1-3H3

InChI key

YJRLSCDUYLRBIZ-UHFFFAOYSA-N

Application

Sulochrin was used as standard in LC/ESI for quantification of analytes from moldy food samples.

Biochem/physiol Actions

Antibiotic from Aspergillus and Penicillium sp. Fungal metabolite; VEGF inhibitor and anti-angiogenic that inhibits the VEGF-induced tube formation of human umbilical vein endothelial cells.
Sulochrin, a metabolite of Aspergillus terreus and Penicillium sp., has weak anti-bacterial and anti-fungal properties. It inhibits the degranulation of eosinophils induced by the platelet activating factor.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
124K1393

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Atsumi Shimada et al.
Bioscience, biotechnology, and biochemistry, 67(2), 442-444 (2003-05-06)
A new plant growth regulator, hydroxysulochrin (1), together with sulochrin (2) was isolated from the culture filtrate of Aureobasidium sp. grown on a malt extract medium. The structures of 1 and 2 were established by spectroscopic methods. 1 and 2
Robin D Couch et al.
Journal of biotechnology, 108(2), 171-178 (2004-05-08)
Elimination of undesirable co-metabolites from industrial fermentations is often required due to the toxicities associated with the contaminants and/or due to difficulties in removing the contaminants during downstream processing. Sulochrin is a co-metabolite produced during the Aspergillus terreus lovastatin fermentation.
Michael Sulyok et al.
Analytical and bioanalytical chemistry, 389(5), 1505-1523 (2007-09-18)
This paper describes the extension of a previously published method based on liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC/ESI-MS/MS) from 39 to currently 87 analytes. Besides the mycotoxins for which regulated concentrations exist, the method now comprises not only almost
Syo Nakajima et al.
Biochemical and biophysical research communications, 440(4), 515-520 (2013-10-09)
Hepatitis C virus (HCV) is a major causative agent of hepatocellular carcinoma. Although various classes of anti-HCV agents have been under clinical development, most of these agents target RNA replication in the HCV life cycle. To achieve a more effective
J Y Liu et al.
Journal of biotechnology, 114(3), 279-287 (2004-11-04)
Aspergillus fumigatus CY018 was recognized as an endophytic fungus for the first time in the leaf of Cynodon dactylon. By bioassay-guided fractionation, the EtOAc extract of a solid-matrix steady culture of this fungus afforded two new metabolites, named asperfumoid (1)
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