publication info
M. Carrington and A.R. Hoelzel, ed., Oxford University Press, 2001, 264 pp., soft cover
manufacturer/tradename
Oxford University Press
General description
This provides an overview of the approaches encompassed by the emerging discipline of molecular epidemiology. Concepts and methods at the forefront of infectious disease studies are discussed along with recent advances in studying host genetics, methods for the detection of mutations and polymorphisms, the relationship between pathologies and immune system genetics, and the use of DNA sequence information to garner insights into the evolution of infectious pathogens. The evolution and function of the immune system and a synopsis of general epidemiological design and analysis are included.
Table of Contents
Introduction to molecular epidemiology, Charles S. Rabkin and Nathaniel Rothman References
1. Epidemiological methods for studies of genetic factors that influence infectious diseases, Eric A. Engels and Thomas R. O′Brien
2. Molecular differentiation of bacterial strains, Eric W. Brown
3. Detection and quantification of heterogeneous viral targets: HIV as a model, Shirley Kwok
4. Mutation detection by single-stranded conformation polymorphism and denaturing high performance liquid chromatography, Michael Dean, Bernard Gerrard, and Rando Allikmets
5. DNA pooling methods for association mapping of complex disease loci, Lisa F. Barcellos, Soren Germer, and William Klitz
6. Single-sperm typing: a rapid alternative to family-based linkage analysis, Michael Cullen and Mary Carrington
7. PCR-based methods of HLA typing, Henry A. Erlich and Elizabeth A. Trachtenberg
8. Evolutionary analysis of molecular sequence data, Austin L. Hughes, Jack da Silva, and Federica Verra
List of suppliers Index
1. Epidemiological methods for studies of genetic factors that influence infectious diseases, Eric A. Engels and Thomas R. O′Brien
2. Molecular differentiation of bacterial strains, Eric W. Brown
3. Detection and quantification of heterogeneous viral targets: HIV as a model, Shirley Kwok
4. Mutation detection by single-stranded conformation polymorphism and denaturing high performance liquid chromatography, Michael Dean, Bernard Gerrard, and Rando Allikmets
5. DNA pooling methods for association mapping of complex disease loci, Lisa F. Barcellos, Soren Germer, and William Klitz
6. Single-sperm typing: a rapid alternative to family-based linkage analysis, Michael Cullen and Mary Carrington
7. PCR-based methods of HLA typing, Henry A. Erlich and Elizabeth A. Trachtenberg
8. Evolutionary analysis of molecular sequence data, Austin L. Hughes, Jack da Silva, and Federica Verra
List of suppliers Index
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