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L0636

Sigma-Aldrich

Lectin from Triticum vulgaris (wheat)

suitable for cell culture, BioReagent, lyophilized powder

Synonym(s):

WGA, Wheat germ agglutinin

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

sterility

aseptically processed

Quality Level

200

product line

BioReagent

form

lyophilized powder

technique(s)

cell culture | mammalian: suitable

impurities

salt, essentially free

storage temp.

2-8°C

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General description

Lectin from Triticum vulgaris (wheat) is a dimeric glycoprotein of 36 kDa. It belongs to the family of chitin-binding proteins. Glycosylated precursor of lectin is synthesized in endoplasmic reticulum.

Application

Lectin from Triticum vulgaris (wheat) has been used:
  • to conjugate with N-hydroxysuccinimide (NHS) dye
  • to inhibit nuclear import
  • to inhibit the nuclear pore of human cervical carcinoma HeLa and SiHa cells

Biochem/physiol Actions

Lectin from Triticum vulgaris (wheat) possessing four binding sites is specific for N-acetyl-d-glucosamine and N-acetyl-d-neuraminic acid (sialic acid) residues. Lectins also function as a fungicide. They also possess anti-nutritive effects.
WGA is not blood group specific but has an affinity for N-acetyl-β-D-glucosaminyl residues and N-acetyl-β-D-glucosamine oligomers. WGA contains no protein-bound carbohydrate.

Other Notes

Highly purified

Preparation Note

Conjugates are prepared from affinity purified lectin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Effects of wheat germ agglutinin on human gastrointestinal epithelium: insights from an experimental model of immune/epithelial cell interaction
Dalla P, et al.
Toxicology and Applied Pharmacology, 237, 146-153 (2009)
Pengfei Zhang et al.
Chemical science, 13(43), 12760-12768 (2022-12-16)
Exosome analysis is a promising tool for clinical and biological research applications. However, detection and biomarker quantification of exosomes is technically challenging because they are small and highly heterogeneous. Here, we report an optical approach for imaging exosomes and quantifying
Super-multiplex vibrational imaging
Wei L, et al.
Nature, 544, 465-465 (2017)
Plant lectins: occurrence, biochemistry, functions and applications
Rudiger H and Gabius HJ
Glycoconjugate Journal, 18, 589-613 (2001)
Jonathan Welch et al.
Regulatory toxicology and pharmacology : RTP, 125, 105022-105022 (2021-08-02)
The aim of the study was to use multiple in vitro assays to assess the effects of a model irritant, sodium dodecyl sulphate (SDS) (≤10 mM (0.29 %, w/v)), on an in vitro model of the airway, MucilAir™. The use of MucilAir™
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