K1750

α-Ketoglutaric acid

≥98.5% (NaOH, titration)

• Synonym(s): 2-Oxoglutaric acid, 2-Oxopentanedioic acid
• Linear Formula: HOOCCH₂CH₂COCOOH
• CAS Number: 328-50-7
• Molecular Weight: 146.10
• Beilstein: 1705689
• EC Number: 206-330-3
• MDL number: MFCD00004165
• UNSPSC Code: 12352204
• PubChem Substance ID: 57654314
• NACRES: NA.32

Properties

• Quality Level: 200
• Assay: ≥98.5% (NaOH, titration)
• form: powder
• solubility: water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
• storage temp.: 2-8°C
• SMILES string: OC(=O)CCC(=O)C(O)=O
• InChI: 1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
• InChI key: KPGXRSRHYNQIFN-UHFFFAOYSA-N

Description

General description

α-Ketoglutaric acid (α-KG) is produced in the tricarboxylic acid cycle.[1]

Application

α-Ketoglutaric acid (α-KG) has been used:

• to study its effects on swine fecal microflora in an in vitro fermentation system[2]
• to study its effects on the activation of CD8⁺ T-cells[3]
• as a substrate in glutamate oxaloacetate transaminase (GOT2) mitochondrial lysate assay[4]

Biochem/physiol Actions

α-Ketoglutaric acid (α-KG) has a wide range of applications in the animal feed, food, pharmaceutical and fine chemistry industries.[1]

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H318
• Precautionary Statements: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves