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HPA021501

Sigma-Aldrich

Anti-DUSP19 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-Dual specificity protein phosphatase 19, Anti-Dual-specificity phosphatase TS-DSP1, Anti-LMW-DSP3, Anti-Protein phosphatase SKRP1, Anti-SAPK pathway-regulating phosphatase 1, Anti-Stress-activated protein kinase pathway-regulating phosphatase 1

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
HPA021501
NACRES:
NA.43

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:50-1:200

immunogen sequence

QEIKAFSRNNLRKQCTRVTTLTGKKIIETWKDARIHVVEEVEPSSGGGCGYVQDLSSDLQVGVIKPWLLLGSQDAAHDLDTL

UniProt accession no.

Q8WTR2

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DUSP19(142679)

General description

Dual specificity protein phosphatase 19 (DUSP19) belongs to the family of mitogen-activated protein kinase phosphatases (MKPs). The catalytic site on phosphatase domain of protein contains aspartic acid, cysteine, and arginine residues. The protein structure also contains N-terminal region made up of two CDC25 homology-2 domains and MAP kinase-binding (MKB) motif or kinase-interacting motif (KIM) which helps in enzyme-substrate interaction. DUSP19 gene is mapped to human chromosome 2.

Immunogen

Dual specificity protein phosphatase 19 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Biochem/physiol Actions

Dual specificity protein phosphatase 19 (DUSP19) is a member of DUSP (dual specificity protein phosphatase) family. Primary function of this protein family is to dephosphorylate both tyrosine and serine/threonine residues of their substrates, and thus function as inactivators of MAPK (mitogen activated kinases). DUSP19 plays a vital role in inhibiting apoptosis of cartilage cells by dephosphorylating JNK (c-Jun N-terminal kinase).

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST73642

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Melinda B Tanzola et al.
Molecular immunology, 43(6), 754-762 (2005-12-20)
Properly regulated mitogen-activated protein (MAP) kinase activity is critical for normal thymocyte development. MAP kinases are activated by phosphorylation of tyrosine and threonine, and dual specificity phosphatases (DUSPs) can inactivate MAP kinases by dephosphorylating both tyrosine and threonine. However, a
Ching-Yu Huang et al.
Cell & bioscience, 2(1), 24-24 (2012-07-10)
Phosphatases are important regulators of intracellular signaling events, and their functions have been implicated in many biological processes. Dual-specificity phosphatases (DUSPs), whose family currently contains 25 members, are phosphatases that can dephosphorylate both tyrosine and serine/threonine residues of their substrates.
Yang Wang et al.
Molecular bioSystems, 12(3), 721-728 (2016-01-12)
Increased mitogen-activated protein kinase (MAPK) activity has been found in human osteoarthritis (OA). Dual specificity protein phosphatase 19 (DUSP19), a member of mitogen-activated protein kinase (MAPK) phosphatases (MKPs), controls the activity of various MAPKs. This study was aimed to explore

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