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About This Item
Empirical Formula (Hill Notation):
C4H9NO4S
CAS Number:
Molecular Weight:
167.18
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥98% (TLC)
storage temp.
−20°C
SMILES string
NC(CCS(O)=O)C(O)=O
InChI
1S/C4H9NO4S/c5-3(4(6)7)1-2-10(8)9/h3H,1-2,5H2,(H,6,7)(H,8,9)
InChI key
PDNJLMZEGXHSCU-UHFFFAOYSA-N
Biochem/physiol Actions
Potent, fast-acting NMDA glutamate receptor agonist.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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W Morishita et al.
Journal of neurophysiology, 82(5), 2556-2564 (1999-11-24)
Depolarization-induced suppression of inhibition (DSI) is a process whereby brief approximately 1-s depolarization to the postsynaptic membrane of hippocampal CA1 pyramidal cells results in a transient suppression of GABA(A)ergic synaptic transmission. DSI is triggered by a postsynaptic rise in [Ca(2+)](in)
K Q Do et al.
Journal of neurochemistry, 46(3), 779-786 (1986-03-01)
Efflux of various amino acids from rat brain slices was determined under resting or depolarizing conditions. Slices of neocortex, hippocampus, striatum, cerebellum, mesodiencephalon, pons-medulla, and spinal cord were depolarized by K+ (50 mM) or veratrine (33 micrograms/ml). The 4-N,N-dimethylamino-azobenzene-4'-isothiocyanate (DABITC)
K Q Do et al.
Journal of neural transmission, 72(3), 185-190 (1988-01-01)
Sulfur containing amino acids such as homocysteic acid (HCA), cysteinsulfinic acid, homocysteinsulfinic acid are released by depolarization of slices from various rat brain regions in a Ca++-dependent manner. L-HCA excites caudate neurons through their N-methyl-D-aspartic acid (NMDA) receptor and potentiates
L Turski et al.
Brain research, 336(1), 162-166 (1985-06-10)
An effect of the beta-stereoisomer of kainic acid on seizures produced by intracerebroventricular injections of excitatory amino acids was tested in mice. beta-Kainic acid preferentially antagonizes myoclonic seizures induced by N-methyl-D-aspartate and quinolinate, has less pronounced anticonvulsant action against alpha-kainate
E R Whittemore et al.
European journal of pharmacology, 192(3), 435-438 (1991-01-17)
Quisqualic acid sensitizes hippocampal CA1 neurons to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4). This sensitization to L-AP4 is known to be blocked by simultaneous exposure to L-homocysteinesulfinic acid, L-alpha-aminoadipic acid and L-serine-O-sulfate during exposure to quisqualate. We report here that these
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