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E0881

Sigma-Aldrich

Elastatinal

powder

Synonym(s):

(2S)-2-[(4S)-2-Amino-1,4,5,6-tetrahydro4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl-L-glutamamide

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About This Item

Empirical Formula (Hill Notation):
C21H36N8O7
CAS Number:
51798-45-9
Molecular Weight:
512.56
Beilstein:
873543
EC Number:
257-426-7
UNSPSC Code:
12352202
PubChem Substance ID:
24894375
NACRES:
NA.77

product name

Elastatinal, microbial

biological source

microbial

form

powder

solubility

water: 20 mg/mL, clear, faintly yellow to yellow

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)N[C@@H](CC(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1

InChI

1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1

InChI key

IJWCGVPEDDQUDE-YGJAXBLXSA-N

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Biochem/physiol Actions

Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K Marossy et al.
Biochimica et biophysica acta, 615(1), 237-245 (1980-09-09)
The extracts of granules isolated from bovine granulocytes show elastase- and chymotrypsin-like activities, as detected with specific synthetic substrates. Extraction of these enzymes depends upon salt concentration. In the course of the present studies a 21-fold purification of the elastase-like
The effect of low-molecular-weight inhibitors on the growth in vitro of a human pancreatic adenocarcinoma cell line.
A G Grant et al.
Biochemical Society transactions, 9(1), 134-134 (1981-02-01)
G Rappay et al.
Life sciences, 36(6), 549-555 (1985-02-11)
Proteinase inhibitors were tested for their ability to inhibit prolactin (PRL) and growth hormone (GH) release by cultured anterior pituitary cells of the rat. Inhibitors of microbial origin (chymostatin, elastatinal, leupeptin) had either no or a moderate effect on hormone
T Kobayashi et al.
Biological & pharmaceutical bulletin, 21(7), 775-777 (1998-08-14)
In order to clarify the degradation of elastin under abnormal conditions, we examined the aortic elastolytic activity in rat experimental diabetes mellitus induced by treatment with streptozotocin and in rat experimental aneurysm induced by treatment with an inhibitor of lysyloxidase
Alexander H Krauland et al.
Journal of controlled release : official journal of the Controlled Release Society, 95(3), 547-555 (2004-03-17)
It was the aim of this study to develop a delivery system providing an improved efficacy of orally administered insulin utilizing a thiolated polymer. 2-Iminothiolane was covalently linked to chitosan. The resulting chitosan-TBA (chitosan-4-thiobutylamidine) conjugate exhibited 453.5+/-64.1 micromol thiol groups
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