E0159

Efonidipine hydrochloride monoethanolate

≥98% (HPLC)

• Empirical Formula (Hill Notation): C₃₄H₃₈N₃O₇P · HCl · C₂H₅OH
• CAS Number: 111011-76-8
• Molecular Weight: 714.18
• MDL number: MFCD00875717
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798945
• NACRES: NA.25

Properties

• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: pale yellow
• solubility: DMSO: >5 mg/mL; H₂O: insoluble
• originator: Shionogi
• storage temp.: 2-8°C
• SMILES string: Cl.CCO.CC1=C(C(c2cccc(c2)[N+]([O-])=O)C(=C(C)N1)P3(=O)OCC(C)(C)CO3)C(=O)OCCN(Cc4ccccc4)c5ccccc5
• InChI: 1S/C34H38N3O7P.C2H6O.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;1-2-3;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;3H,2H2,1H3;1H
• InChI key: IKBJGZQVVVXCEQ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Racemic efonidipine has both L-type and T-type calcium channel blocking activity. The R(−)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.

Features and Benefits

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves