Skip to Content
Merck
All Photos(1)

Documents

B5311

Sigma-Aldrich

Biperiden hydrochloride

≥98% (HPLC), powder

Synonym(s):

1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride, Akineton, Akinophyl

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C21H30ClNO
CAS Number:
Molecular Weight:
347.92
EC Number:
UNSPSC Code:
12352200
PubChem Substance ID:

Assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: >20 mg/mL
H2O: insoluble

originator

Abbott

SMILES string

Cl[H].OC(CCN1CCCCC1)(C2CC3CC2C=C3)c4ccccc4

InChI

1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H

InChI key

RDNLAULGBSQZMP-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128)

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. It is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy. LD50 in rats 750 mg/kg; in dogs 340 mg/kg.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Marina S Zacarias et al.
Neuroscience letters, 513(2), 129-131 (2012-02-18)
It is well-known that cocaine dependence is a public health issue, and several studies stress the need to look for new and more effective treatments. Although the mesolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and
Use of anticholinergic drugs and worsening of pemphigus foliaceus in a patient with bipolar disorder.
Lúcio Botelho-Nogueira et al.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 33(4), 412-413 (2011-12-23)
Elmorsy Khaled et al.
Talanta, 87, 40-45 (2011-11-22)
The construction and performance characteristics of Biperiden (BP) polyvinyl chloride (PVC) electrodes are described. Different methods for electrode fabrication are tested including; incorporation of BP-ion pairs (BP-IPs), incorporation of ion pairing agents, or soaking the plain electrode in BP-ion pairs
Anna C Ramos et al.
Behavioural brain research, 231(1), 213-216 (2012-04-04)
Cocaine addiction is a public health issue in many countries, stressing the need for more effective treatments. As all drugs of abuse, cocaine acts on the brain reward system, increasing dopamine (DA) levels. Other neurotransmitters such as acetylcholine (ACh) are
W Sperling et al.
Medical hypotheses, 76(5), 720-722 (2011-03-04)
In a regions of interest analysis (ROI) of the most frequent psychiatric disorders (schizophrenia, depression, anxiety, addiction), we found the nucleus lentiformis to be the topographical brain region most frequently cited in connection with these disorders in a regions of

Articles

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service