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39968

NIR 5c

Name: NIR 5c
Brand: SIGMA

≥80% (HPCE), BioReagent, suitable for fluorescence

Synonym(s):

1,1′-Bis(3-aminopropyl)-11-chloro-4,5:4′,5′-dibenzo-3,3,3′,3′-tetramethyl-10,12-trimethylenindotricarbocyanine bromide dihydrobromide

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About This Item

Empirical Formula (Hill Notation):

C₄₄H₅₀BrClN₄ · 2HBr

CAS Number:

162411-30-5

Molecular Weight:

912.08

MDL number:

MFCD09752028

UNSPSC Code:

12352200

PubChem Substance ID:

24864833

product line

BioReagent

Assay

≥80% (HPCE)

fluorescence

λ_ex 820 nm; λ_em 834 nm in methanol

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

[Br-].Br[H].Br[H].CC1(C)\C(=C/C=C2\CCCC(\C=C\C3=[N+](CCCN)c4ccc5ccccc5c4C3(C)C)=C2Cl)N(CCCN)c6ccc7ccccc7c16

Application

NIR 5c, a near-infrared (NIR) fluorescence dye, is used in applications where the intrinsic fluorescence of biomolecules poses a problem in the assay. Near-infrared (NIR) fluorescence (650–900 nm) detection avoids the natural background fluorescence interference of biomolecules, providing a high contrast between target and background tissues.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Certificates of Analysis (COA)

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NIR fluorescent biotinylated cyanine dye: optical properties and combination with quantum dots as a potential sensing device.

Menendez GO, Eva Pichel M, et al.

Photochemistry and Photobiology, 12, 236-240 (2013)

High-throughput NIR-chemometric methods for determination of drug content and pharmaceutical properties of indapamide tablets.

Ioan Tomuta et al.

Journal of pharmaceutical and biomedical analysis, 84, 285-292 (2013-01-26)

This paper describes the development, validation and application of NIR-chemometric methods for API content and pharmaceutical characterization (disintegration time and crushing strength) of indapamide intact tablets. Development of the method for chemical characterization was performed on samples corresponding to 80

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