HRNKLMAG-51K-01
MILLIPLEX® Human RANKL Magnetic Bead- Single Plex - Metabolism Assay
This MILLIPLEX MAP Human RANKL Magnetic Bead- Single Plex, HRNKLMAG-51K-01 is a Metabolism single plex assay. The analyte available for this kit is RANKL.
Synonym(s):
Human RANKL Detection, Human RANKL Magnetic Beads, RANKL Magnetic Bead Kit
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About This Item
UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.47
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Quality Level
species reactivity
human
manufacturer/tradename
Milliplex®
assay range
accuracy: 92%
sensitivity: 5.0 pg/mL
standard curve range: 4.88-20,000 pg/mL
technique(s)
multiplexing: suitable
compatibility
configured for Single Plex
detection method
fluorometric (Luminex xMAP)
shipped in
wet ice
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General description
Bone metabolism is the dynamic process of ongoing bone deposition and re-absorption, controlled by osteoblasts, osteocytes, and osteoclasts. While osteoblasts and osteocytes (osteoblasts surrounded by matrix) are responsible for bone deposition, osteoclasts are responsible for bone resorption. Both are required to maintain bone structure, as well as an adequate supply of calcium. To maintain metabolic balance these cells rely on complex signaling pathways involving hormones and cytokines to achieve appropriate rates of growth and differentiation. The protein Receptor Activator for Nuclear Factor B Ligand (RANKL) activates osteoclasts and has been implicated in degenerative bone diseases such as rheumatoid arthritis and osteomyelitis.
MILLIPLEX® Human RANKL Single Plex Kit is used for the quantification of RANKL in human serum, plasma and cell / tissue culture supernatant samples. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Bone
MILLIPLEX® Human RANKL Single Plex Kit is used for the quantification of RANKL in human serum, plasma and cell / tissue culture supernatant samples. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Bone
Application
- Analyte: RANKL
- Recommended Sample Type: Human serum, plasma, cell/tissue culture supernatants and lysates
- Recommended Sample Dilution: 25 uL per well of 1:2 diluted serum or plasma; cell/tissue culture samples may require dilution with an appropriate control medium.
- Assay Run Time: Overnight (16-18 hr) at 2-8°C
- Research Category: Metabolism
- Research Subcategory: Bone
Packaging
Everything you need in a single kit.
Other Notes
Please contact Technical Service for linearity of dilution.
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Certificates of Analysis (COA)
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Janaina Ramalho et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 34(9), 1574-1584 (2019-07-04)
Bone mineral density (BMD) loss is a known complication of human immunodeficiency virus (HIV) infection and its treatment, particularly with tenofovir disoproxil fumarate (TDF)-containing antiretroviral regimens. Although renal proximal tubular dysfunction and phosphaturia is common with TDF, it is unknown
Panagiota Klentrou et al.
Children (Basel, Switzerland), 8(11) (2021-11-28)
Thirteen female adolescent soccer players (14.3 ± 1.3 years) participated in a cross-over, double-blind trial examining the effects of Greek yogurt (GY) consumption on bone biomarkers during 5 days of intense soccer training. The study took place over two intervention
Maria H Pham et al.
Journal of tissue engineering, 10, 2041731419828950-2041731419828950 (2019-02-26)
The attachment of implants relies on bone and soft tissue biocompatibility. The aim of this article is to investigate the effect of fluoride-modified metallic titanium (Ti) surfaces (Ti-F) on proliferation and differentiation of human gingival fibroblasts. Human gingival fibroblast cells
Péter Jávor et al.
International journal of molecular sciences, 23(14) (2022-07-28)
There is growing evidence regarding the role of mitochondrial dysfunction in osteoarthritis (OA) and rheumatoid arthritis (RA). However, quantitative comparison of synovial mitochondrial derangements in these main arthritis forms is missing. A prospective clinical study was conducted on adult patients
Joel L Prowting et al.
Frontiers in nutrition, 9, 840973-840973 (2022-05-17)
Dairy products and impact exercise have previously been identified to be independently beneficial for bone mineral properties, however, it is unknown how the combination of these two osteogenic interventions may alter acute bone turnover. Using a randomized crossover design, we
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Multiplex immunoassays save time and sample volume in metabolic syndrome research, providing comprehensive insights into related conditions.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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