ABT241
Anti-acetyl Tubulin (Lys40) Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
Tubulin alpha-1A chain, Alpha-tubulin 3, Tubulin B-alpha-1, Tubulin alpha-3 chain
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
rat (based on 100% sequence homology), bovine (based on 100% sequence homology), mouse (based on 100% sequence homology)
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
acetylation (Lys40)
Gene Information
human ... TUBA1A(7846)
General description
Tubulin is the major constituent of microtubules, and microtubules are major cytoskeletal elements. Tubulin proteins undergo a number of post-translational modifications both during individual synthesis and after complete tubule formation. Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects the affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.
Immunogen
Epitope: Near N-Terminus
KLH-conjugated linear peptide corresponding to a region near the near N-Terminus of human Tubulin acetylated at Lys40.
Application
Anti-acetyl Tubulin (Lys40) Antibody is an antibody against acetyl Tubulin (Lys40) for use in western blotting.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeleton
Cytoskeleton
Quality
Evaluated by Western Blotting in untreated and Trichostatin A treated HeLa cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected acetyl Tubulin (Lys40) in 10 µg of Trichostatin A treated HeLa cell lysate, and not in untreated HeLa cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected acetyl Tubulin (Lys40) in 10 µg of Trichostatin A treated HeLa cell lysate, and not in untreated HeLa cell lysate.
Target description
~50 kDa observed
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Joseph M Varberg et al.
mSphere, 1(1) (2016-06-16)
Toxoplasma gondii is a widespread protozoan parasite that causes potentially life-threatening opportunistic disease. New inhibitors of parasite replication are urgently needed, as the current antifolate treatment is also toxic to patients. Microtubules are essential cytoskeletal components that have been selectively
Rodolpho Ornitz Oliveira Souza et al.
Journal of cell science, 135(22) (2022-11-01)
The single mitochondrion of Toxoplasma gondii is highly dynamic, being predominantly in a peripherally distributed lasso-shape in intracellular parasites and collapsed in extracellular parasites. The peripheral positioning of the mitochondrion is associated with apparent contacts between the mitochondrion membrane and
Kylie Jacobs et al.
mBio, 11(1) (2020-02-13)
Toxoplasma gondii's single mitochondrion is very dynamic and undergoes morphological changes throughout the parasite's life cycle. During parasite division, the mitochondrion elongates, enters the daughter cells just prior to cytokinesis, and undergoes fission. Extensive morphological changes also occur as the
Ayad A Al-Hamashi et al.
Bioorganic chemistry, 116, 105297-105297 (2021-09-13)
Despite the advances in treatment strategies, cancer is still the second leading cause of death in the USA. A majority of the currently used cancer drugs have limitations in their clinical use due to poor selectivity, toxic side effects and
Rayna Rosati et al.
Molecular pharmacology, 90(3), 225-237 (2016-07-07)
Histone deacetylase inhibitors (HDACIs) can disrupt the viability of prostate cancer (PCa) cells through modulation of the cytosolic androgen receptor (AR) chaperone protein heat shock protein 90 (HSP90). However, toxicities associated with their pleiotropic effects could contribute to the ineffectiveness
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