AB5308
Anti-Presenilin-1 Antibody, loop, a.a. 275-367, CT
serum, Chemicon®
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
hamster, human, mouse, monkey
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... PSEN1(5663)
Specificity
Presenilin-1, Loop.
Immunogen
Epitope: loop, a.a. 275-367, C-terminus
Human Presenilin-1 (amino acids 275-367) fused to C-terminus of maltose binding protein.
Application
Anti-Presenilin-1 Antibody, loop, a.a. 275-367, C-terminus is an antibody against Presenilin-1 for use in IP, WB & IC.
Immunocytochemistry: Cos7, SY5Y cell lines.
Western blot: 1:500-1:3000
Immunoprecipitation.
Optimal working dilutions must be determined by end user.
Western blot: 1:500-1:3000
Immunoprecipitation.
Optimal working dilutions must be determined by end user.
Physical form
Rabbit serum. Liquid in PBS with 0.01% sodium azide.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Description
Pricing
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Lisa Placanica et al.
Biochemistry, 49(13), 2796-2804 (2010-02-25)
Gamma-secretase is a widely expressed multisubunit enzyme complex which is involved in the pathogenesis of Alzheimer disease and hematopoietic malignancies through its aberrant processing of the amyloid precursor protein (APP) and Notch1, respectively. While gamma-secretase has been extensively studied, there
Hanna Laudon et al.
Journal of neurochemistry, 89(1), 44-53 (2004-03-20)
The enzyme gamma-secretase catalyzes the intramembrane proteolytic cleavage that generates the amyloid beta-peptide from the beta-amyloid precursor protein. The presenilin (PS) protein is one of the four integral membrane protein components of the mature gamma-secretase complex. The PS protein is
Theodore A Sarafian et al.
Journal of neuroscience research, 95(9), 1871-1887 (2017-01-25)
The α-synuclein protein exists in vivo in a variety of covalently modified and aggregated forms associated with Parkinson's disease (PD) pathology. However, the specific proteoform structures involved with neuropathological disease mechanisms are not clearly defined. Since α-synuclein plays a role
Arnaldo Parra-Damas et al.
Scientific reports, 7(1), 18004-18004 (2017-12-23)
Gene expression mediated by the transcription factor cAMP-responsive element-binding protein (CREB) is essential for a wide range of brain processes. The transcriptional coactivartor CREB-regulated transcription coactivator-1 (CRTC1) is required for efficient induction of CREB target genes during neuronal activity. However, the mechanisms regulating induction of specific CREB/CRTC1-dependent
Grant T Corbett et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8445-8450 (2015-06-17)
Amyloid precursor protein (APP) derivative β-amyloid (Aβ) plays an important role in the pathogenesis of Alzheimer's disease (AD). Sequential proteolysis of APP by β-secretase and γ-secretase generates Aβ. Conversely, the α-secretase "a disintegrin and metalloproteinase" 10 (ADAM10) cleaves APP within
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