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Sigma-Aldrich

MMP-2/MMP-9 Inhibitor II

The MMP-2/MMP-9 Inhibitor II, also referenced under CAS 193807-60-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

MMP-2/MMP-9 Inhibitor II, (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide, BiPS, BiPS

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About This Item

Empirical Formula (Hill Notation):
C21H20N2O4S
CAS Number:
193807-60-2
Molecular Weight:
396.46
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 100 mg/mL
methanol: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A potent inhibitor of MMP-2 (IC50 = 17 nM) and MMP-9 (IC50 = 30 nM). Also shown to potently induce and rapidly activate HIF. Reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.
A potent inhibitor of type IV collagenases, MMP-2 (IC50 = 17 nM) and MMP-9 (IC50 = 30 nM). Also shown to potently induce and rapidly activate HIF. Has been shown in vivo to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.

Biochem/physiol Actions

Cell permeable: no
Primary Target
MMP-2
Product does not compete with ATP.
Reversible: no
Target IC50: 17 nM, 30 nM against MMP-2, and MMP-9, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Lauzier, M.C., et al. 2008. Mol. Pharmacol.In press.
Mifune, M., et al. 2005. J. Biol. Chem.280, 26592.
Zhang, H., et al. 2004. Circ. Res.95, 989.
Tamura, Y., et al. 1998. J. Med. Chem.41, 640.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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