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Sigma-Aldrich

Anti-dimethyl-Histone H4 (Lys20) Antibody, clone 6G7/H4

clone 6G7/H4, Upstate®, from mouse

Synonym(s):

H4K20me2, Histone H4 (di methyl K20)

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody product type

primary antibodies

clone

6G7/H4, monoclonal

species reactivity

human, bovine, mouse, rat

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_175054

UniProt accession no.

P62805

shipped in

dry ice

target post-translational modification

dimethylation (Lys20)

Gene Information

bovine ... H4C1(617905)
human ... H4C1(8359)
mouse ... H4C1(326619)

Specificity

methyl-Histone H4

Immunogen

peptide corresponding to amino acids 17-28 of human histone H4 (RHRdimKVLRDNIQGC) dimethylated on lysine 20.

Application

Research Category
Epigenetics & Nuclear Function
Research Sub Category
Histones
Use Anti-dimethyl-Histone H4 (Lys20) Antibody, clone 6G7/H4 (mouse monoclonal antibody) validated in IP, WB, IHC to detect dimethyl-Histone H4 (Lys20) also known as H4K20me2, Histone H4 (di methyl K20).

Quality

routinely evaluated by immunoblot on HeLa acid extracts

Target description

10kDa

Physical form

Format: Purified
PBS
Protein G Chromatography

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kenichi Nishioka et al.
Molecular cell, 9(6), 1201-1213 (2002-06-28)
We have purified a human histone H4 lysine 20 methyltransferase and cloned the encoding gene, PR/SET07. A mutation in Drosophila pr-set7 is lethal: second instar larval death coincides with the loss of H4 lysine 20 methylation, indicating a fundamental role
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.
Frederick A Mallette,Francesca Mattiroli,Gaofeng Cui,Leah C Young,Michael J Hendzel et al.
The Embo Journal null
Ai-Shun Guo et al.
Molecular medicine reports, 14(5), 4613-4621 (2016-10-26)
The present study aimed to investigate the differential expression and clinical significance of histone methyltransferase G9a, histone H3K9me2 and histone H3K9me1 in human brain glioma and adjacent tissue samples. It also aimed to observe the effect and mechanism of BIX‑01294, as

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