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880134P

Avanti

PMA

Avanti Research™ - A Croda Brand (880134P), powder

Synonym(s):

Polymethacrylate Copolymer (N-C4-52-6.9)

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.25

Assay

99% (NMR)

form

powder

packaging

pkg of 1 × 100 mg (880134P-100mg)
pkg of 1 × 500 mg (880134P-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand (880134P)

shipped in

dry ice

storage temp.

−20°C

SMILES string

C[N+](C)(C)CCOC(C(C)(CC(C)([H])C(OCCCC)=O)CSCCC(OC)=O)=O.[Cl-]

General description

PMA (polymethacrylate) random copolymer is amphiphilic and consists of hydrophobic and hydrophilic sidechains.

Biochem/physiol Actions

PMA (polymethacrylate) forms nanodiscs spontaneously by fragmentation or solubilization of the lipid bilayers. It is used in designing of nanodisc-forming polymer to mimic the amphiphilic nature of proteins and peptides. PMA N−C4−60−4.7 efficiently solubilised the lipid membrane and forms lipid nanodiscs with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC). The addition of PMA N−C4−60−4.7 lowered the light scattering intensity of Escherichia coli suspension.

Packaging

20mL clear glass screw cap vial (880134P-500mg)
5mL glass amber screw cap vial (880134P-100mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Spontaneous lipid nanodisc fomation by amphiphilic polymethacrylate copolymers
Yasuhara K, et al.
Journal of the American Chemical Society, 139(51), 18657-18663 (2017)
Juan Francisco Bada Juarez et al.
Chemistry and physics of lipids, 221, 167-175 (2019-04-04)
Nanoparticles assembled with poly(styrene-maleic acid) copolymers, identified in the literature as Lipodisq, SMALPs or Native Nanodisc, are routinely used as membrane mimetics to stabilise protein structures in their native conformation. To date, transmembrane proteins of varying complexity (up to 8

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