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912034

Sigma-Aldrich

Trimethyl chitosan

high molecular weight, degree of quaternization 30-70%

Synonym(s):

N,N,N-Trimethyl chitosan, Chitosan trimethyl, Mucoadhesive polymers, TMC Chitosan

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About This Item

Linear Formula:
(C9H18ClNO4)n
CAS Number:
52349-26-5
UNSPSC Code:
12162002
NACRES:
NA.23

Quality Level

100

form

powder

color

light yellow to light brown

storage temp.

2-8°C

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Application

Chitosan offers remarkable biological properties, it has been widely used in drug delivery and tissue engineering applications. Chitosan has good mucoadhesive properties due to its positive charge, which increases the adhesion to mucosa and facilitates drug penetration. Also, chitosan possesses hemostatic properties, which makes it a good candidate for wound dressing applications.

The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Among all the quaternized chitosans, N, N, N-trimethyl chitosan chloride (TMC) is the most widely applied in biomedical applications.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Preparation and Characterization of Particles from Chitosan with Different Molecular Weights and Their Trimethyl Chitosan Derivatives for Nasal Immunization.
Boonyo W, et al.
Journal of Metals, Materials and Minerals, 18(2), 59-65 (2008)
Rajesh Kumar Kainthan et al.
Biomaterials, 27(31), 5377-5390 (2006-07-21)
A novel class of hyperbranched polymers based on polyglycerol (PG) and poly(ethylene glycol) (PEG) are synthesized by multibranching anionic ring opening polymerization. Multivalent cationic sites are added to these polymers by a post-amination and quarternization reactions. Blood compatibility studies using
Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering.
Riva R, et al.
Advances in Polymer Science, 244, 19-44 (2011)
Mohamed H Ramadan et al.
Langmuir : the ACS journal of surfaces and colloids, 30(25), 7485-7495 (2014-06-04)
We report a thermoresponsive chemical modification strategy of hyaluronic acid (HA) for coating onto a broad range of biomaterials without relying on chemical functionalization of the surface. Poly(di(ethylene glycol) methyl ether methacrylate) (PMEO2MA), a polymer with a lower critical solution
Rajesh Kumar Kainthan et al.
Biomacromolecules, 9(3), 886-895 (2008-02-06)
This paper discusses the binding and release properties of hydrophobically modified hyperbranched polyglycerol-polyethylene glycol copolymers that were originally developed as human serum albumin (HSA) substitutes. Their unimolecular micellar nature in aqueous solution has been proven by size measurements and other
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