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84570

Sigma-Aldrich

Sarcosine methyl ester hydrochloride

≥97.0% (T)

Synonym(s):

N-Methylglycine methyl ester hydrochloride

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About This Item

Linear Formula:
CH3NHCH2COOCH3 · HCl
CAS Number:
13515-93-0
Molecular Weight:
139.58
Beilstein:
3619268
EC Number:
236-853-2
MDL number:
MFCD00038876
UNSPSC Code:
12352108
PubChem Substance ID:
57653011
NACRES:
NA.22

Quality Level

100

Assay

≥97.0% (T)

form

powder

reaction suitability

reaction type: solution phase peptide synthesis

impurities

≤3% sarcosine hydrochloride

mp

117-119 °C (lit.)

application(s)

peptide synthesis

SMILES string

Cl.CNCC(=O)OC

InChI

1S/C4H9NO2.ClH/c1-5-3-4(6)7-2;/h5H,3H2,1-2H3;1H

InChI key

HQZMRJBVCVYVQA-UHFFFAOYSA-N

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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D O H Teare et al.
The journal of physical chemistry. B, 109(44), 20923-20928 (2006-07-21)
A new class of protein-resistant film based on N-substituted glycine derivatives is described. Pulsed plasma deposited poly(N-acryloylsarcosine methyl ester) coatings are shown to be resistant toward the adsorption of fibrinogen and lysozyme. Deposition and UV irradiation of the polymer through
A Sener et al.
Endocrinology, 117(1), 237-242 (1985-07-01)
The Ca2+-responsive enzyme transglutaminase, which catalyzes the cross-bridging of proteins, is present in pancreatic islet cells, but its participation in the process of insulin release remains to be documented. Glycine methylester (1.0-10.0 mM) inhibited, in a dose-related manner, transglutaminase activity
C Alarcon et al.
Bioscience reports, 5(7), 581-587 (1985-07-01)
Glycine methyl ester, an inhibitor of transglutaminase, decreased glucose-stimulated insulin release and delayed proinsulin conversion in rat pancreatic islets pulse-labelled with L-[4-3H]phenylalanine. Sarcosine methyl ester, which does not inhibit transglutaminase activity, failed to affect insulin release and proinsulin conversion. The
M A Lindsay et al.
Bioscience reports, 10(6), 557-561 (1990-12-01)
Ca(2+)-Induced insulin release from electropermeabilised islets is inhibited by the transglutaminase inhibitors monodansylcadaverine, glycine methylester, methylamine and cystamine but not by the control compounds dimethyl monodansylcadaverine and sarcosine methylester which lack the primary amine group. Neither monodansylcadaverine nor glycine methylester
A M Bersten et al.
Biochimica et biophysica acta, 762(3), 429-436 (1983-06-02)
The effects of competitive inhibitors of transglutaminase on the formation of myotubes by the fusion of myoblasts in vitro has been investigated. Myotube formation was inhibited when myoblasts from 11-day-old chick embryos were cultured in vitro in the presence of

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