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Key Documents

147508

Sigma-Aldrich

Fertilysin™

97%

Synonym(s):

N,N′-Bis(dichloroacetyl)-1,8-octamethylenediamine, N,N′-Octamethylenebis(2,2-dichloroacetamide), N,N′-Octamethylenebis(dichloroacetamide)

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About This Item

Empirical Formula (Hill Notation):
C12H20Cl4N2O2
CAS Number:
Molecular Weight:
366.11
EC Number:
MDL number:
UNSPSC Code:
12352103

Assay

97%

SMILES string

ClC(Cl)C(=O)NCCCCCCCCNC(=O)C(Cl)Cl

Pictograms

Health hazardExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Effect of N,N'-bis(dichloroacetyl)-i,8-octamethylenediamine (WIN 18446) on the testis + epididymis of the musk shrew Suncus murinus L.
S K Singh et al.
Indian journal of experimental biology, 18(11), 1217-1220 (1980-11-01)
K Momma et al.
Fetal diagnosis and therapy, 7(1), 46-52 (1992-01-01)
We studied 11 fetal rats with normal heart and diaphragmatic hernia induced by administration of bis-diamine (200 mg) on the 9th and 10th day of pregnancy. After rapid whole-body freezing on the 21st day, the fetuses were studied by means
G Oster et al.
Clinical immunology and immunopathology, 28(1), 128-134 (1983-07-01)
The DiGeorge syndrome, a variable complex of thymic aplasia, congenital heart disease, hypoparathyroidism, and anomalies of the face and neck, is thought to result from exposure to teratogenic agents. A group of congenital defects closely resembling this syndrome can be
Cathryn A Hogarth et al.
Biology of reproduction, 84(5), 957-965 (2011-01-07)
Bis-(dichloroacetyl)-diamines (BDADs) are compounds that inhibit spermatogenesis and function as male contraceptives in many species; however, their mechanism of action has yet to be fully investigated. It has been proposed that BDADs may function via inhibition of testicular retinoic acid
John K Amory et al.
Journal of andrology, 32(1), 111-119 (2010-08-14)
The bisdichloroacetyldiamine WIN 18,446 reversibly inhibits spermatogenesis in many species, including humans; however, the mechanism by which WIN 18,446 functions is unknown. As retinoic acid is essential for spermatogenesis, we hypothesized that WIN 18,446 might inhibit retinoic acid biosynthesis from

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