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Key Documents

SCP0123

Sigma-Aldrich

[D-Gln4]-Desmopressin

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About This Item

Empirical Formula (Hill Notation):
C46H64N14O12S2
Molecular Weight:
1069.22
UNSPSC Code:
12352209
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥75%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Mpa-Tyr-Phe-D-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2

Application

Desmopressin is a synthetic alternative to arginine vasopressin that acts via V2 receptors in renal collecting ducts to regulate water retention. [D-Gln4]-Desmopressin may be used in studies of conformations and receptor activity of desmopressin analogues.

Biochem/physiol Actions

Desmopressin is considered safe for consumption during first and second trimesters of pregnancy. But, it shows high risk of arterial thrombosis. It is known to induce platelet factor VIII and VWF (Von Willebrand factor) and improves platelet aggregation. Desmopressin is found helpful in congenital bleeding disorder.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 63-63 (2014)
Platelets, 1243-1243 (2011)
J Wang et al.
International journal of peptide and protein research, 45(5), 471-481 (1995-05-01)
The solution structures of desmopressin, a nine-residue peptide with specific antidiuretic and antibleeding activities, have been studied in aqueous and TFE-containing solutions by two-dimensional NMR and molecular modeling techniques. It is found that TFE induces a conformational change of the
Mattias Hedenström et al.
Journal of medicinal chemistry, 45(12), 2501-2511 (2002-05-31)
Three analogues of the antidiuretic drug desmopressin ([1-desamino,8-D-arginine]vasopressin) have been prepared. In two of these, gamma-turn mimetics based on a morpholin-3-one framework have been inserted instead of residues Phe3-Asn5, whereas the third analogue has a methylene ether isostere in place

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