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RAB0697

Sigma-Aldrich

Human IL23A / Interleukin-23 Subunit Alpha ELISA Kit

for serum, plasma, cell culture supernatants and urine

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type cell culture supernatant(s)
sample type serum
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 25 pg/mL
standard curve range: 28.67-7000 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL23A(51561)

General description

Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated DC (dendritic cells) and macrophages. It is a 20.7 kDa protein that has 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.
The IL23A ELISA kit provides for the Quantitative measurement of IL-23 in Cell Culture Supernatants, Plasma and Serum.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Interleukin-23 (IL-23) plays a major role in cutaneous immune-mediated inflammatory diseases like psoriasis, allergic contact dermatitis and atopic dermatitis. It is involved in cellular immunity driving the expansion, stabilization and survival of Th17 cells.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

Product No.
Description
SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABELADEELISA 5X Assay/Sample Diluent Buffer E (Item E2)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Paola Miyazato et al.
Retrovirology, 16(1), 38-38 (2019-12-18)
Human T cell leukaemia virus type 1 (HTLV-1) is a retrovirus associated with human diseases such as adult T-cell leukaemia/lymphoma and HTLV-1 associated myelopathy/tropical spastic paraparesis. In contrast to another human retrovirus, human immunodeficiency virus type 1 (HIV-1), HTLV-1 persists
IL23A (interleukin 23, alpha subunit p19).
Inoue N.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2011)
Heng-Xiu Yan et al.
Immunologic research, 60(1), 112-126 (2014-06-05)
Psoriasis is a common chronic T-cell-mediated autoimmune skin disease, and traditional immunotherapies for psoriasis have focused on the direct inhibition of T cells, which often causes toxicity and lacks long-term effectiveness. Safe and effective therapeutic strategies are strongly needed for
Ho-Jae Lee et al.
Antioxidants (Basel, Switzerland), 9(10) (2020-10-24)
Immune activation associates with the intracellular generation of reactive oxygen species(ROS). To elicit effective immune responses, ROS levels must be balanced. Emerging evidenceshows that ROS-mediated signal transduction can be regulated by selenoproteins such asmethionine sulfoxide reductase B1 (MsrB1). However, how
Anna Olewicz-Gawlik et al.
International journal of rheumatic diseases, 17(6), 664-670 (2014-01-29)
T cell abnormalities with a focus on Th17 cells have been associated with the pathogenesis of systemic sclerosis (SSc) and interstitial lung disease (ILD). The aim of this study was to evaluate serum levels of interleukin (IL)-17, IL-21 and IL-23
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