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Key Documents

N9879

Sigma-Aldrich

NADase from porcine brain

≥0.007 unit/mg solid

Synonym(s):

DPN Nucleosidase, NAD+ glycohydrolase

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About This Item

CAS Number:
Enzyme Commission number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54

form

powder

Quality Level

specific activity

≥0.007 unit/mg solid

solubility

insoluble

storage temp.

−20°C

General description

NADase is a glycohydrolase that catalyzes ADP-ribose transfer.

Application

NADase from porcine brain has been used in a study to investigate histidine and related compounds resulting from catalyzed ADP-riboslyation. It has also been used in a study to investigate the preparation of arylazide-substituted pyridine adenine dinucleotides for photoaffinity labeling.

Biochem/physiol Actions

Nicotinamide has been shown to inhibit NADase activity.

Unit Definition

One unit will hydrolyze 1.0 μmole of β-NAD to nicotinamide and ADP-ribose per min at pH 7.3 at 37 °C.

Physical form

Acetone-dried powder

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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D San Segundo et al.
Transplantation proceedings, 44(9), 2676-2678 (2012-11-14)
Posttransplant infection after lung transplantation is a common feature due to the immunodeficiency induced by the immunosuppressive load. To assess B-cell subsets in lung transplant recipients suffering at least one episode of infection within the first year posttransplantation. Twenty-eight lung
Shoko Nakayama et al.
Hematology (Amsterdam, Netherlands), 17(6), 317-320 (2012-11-22)
The accurate determination of cytoplasmic immunoglobulin (cIg) light chain (LC) expression is important to differentiate reactive plasmacytosis from a clonal plasma cell neoplasm such as plasma cell myeloma (PCM). Through retrospective analysis, we studied the cytoplasmic kappa/lambda ratio of CD38-positive
Nicholas Chiorazzi
Hematology. American Society of Hematology. Education Program, 2012, 76-87 (2012-12-13)
Several prognostic markers based on genetic, phenotypic, and molecular characteristics of chronic lymphocytic leukemia (CLL) B cells have emerged in the past decade. The clinical utility of these newer prognostic indicators, alone or in combination with each other and other
Ding-bao Chen et al.
Zhonghua bing li xue za zhi = Chinese journal of pathology, 41(9), 607-612 (2012-11-20)
To study the clinical and histopathologic features, diagnosis, pathogenesis and therapy of post-transplant lymphoproliferative disorders (PTLD). The clinical and pathologic features of 15 cases of PTLD were retrospectively analyzed by light microscopy, immunohistochemistry and in-situ hybridization, according to the updated
Evidence for Enzymatic ADP-Ribosylation to Histidine and Related Dipeptides
Tono-oka, S., et al.
Acta Chemica Scandinavica, 48, 780-782 (1994)

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