C2196
L-Cysteine S-sulfate
≥98% (TLC), suitable for ligand binding assays
Synonym(s):
S-Sulfo-L-cysteine
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About This Item
Empirical Formula (Hill Notation):
C3H7NO5S2
CAS Number:
Molecular Weight:
201.22
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
1726832
Product Name
L-Cysteine S-sulfate, ≥98% (TLC)
Quality Level
assay
≥98% (TLC)
form
powder
technique(s)
ligand binding assay: suitable
color
white
storage temp.
−20°C
SMILES string
N[C@@H](CSS(O)(=O)=O)C(O)=O
InChI
1S/C3H7NO5S2/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/t2-/m0/s1
InChI key
NOKPBJYHPHHWAN-REOHCLBHSA-N
Biochem/physiol Actions
L-Cysteine S-sulfate (LCSS) is used as an NMDA glutamatergic receptor agonist. It serves as a substrate for cystine lyase(s).
Cysteine is one of the functional amino acids that are associated with growth, reproduction, maintenance and immunity. Cysteine is a source of disulfide linkage in protein and is associated with sulfur transport. At physiological pH, cysteine undergoes rapid oxidation to form cystine. Reduced availability of cysteine or cystine, influences leukocyte metabolism. L-Cysteine serves as a precursor for the rate limiting step in glutathione synthesis that occurs in neurons. It donates inorganic sulfate for detoxification reactions. Therefore, L-cysteine might be associated with neuroprotection. It is found to obstruct the entry of heavy metal ions across the blood-brain barrier into the brain. Increased levels of L-cysteine might lead to neurotoxicity.
Cysteine is one of the functional amino acids that are associated with growth, reproduction, maintenance and immunity. Cysteine is a source of disulfide linkage in protein and is associated with sulfur transport. At physiological pH, cysteine undergoes rapid oxidation to form cystine. Reduced availability of cysteine or cystine, influences leukocyte metabolism. L-Cysteine serves as a precursor for the rate limiting step in glutathione synthesis that occurs in neurons. It donates inorganic sulfate for detoxification reactions. Therefore, L-cysteine might be associated with neuroprotection. It is found to obstruct the entry of heavy metal ions across the blood-brain barrier into the brain. Increased levels of L-cysteine might lead to neurotoxicity.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Mechanisms of L-Cysteine Neurotoxicity
R. Janaky
Neurochemical Research, 25, 1397-1405 (2000)
Cecilia Gotor et al.
Plant signaling & behavior, 5(8), 1028-1030 (2010-08-12)
The cysteine molecule plays an essential role in cells because it is part of proteins and because it functions as a reduced sulfur donor molecule. In addition, the cysteine molecule may also play a role in the redox signaling of
Claus Jacob et al.
Angewandte Chemie (International ed. in English), 42(39), 4742-4758 (2003-10-17)
Sulfur and selenium occur in proteins as constituents of the amino acids cysteine, methionine, selenocysteine, and selenomethionine. Recent research underscores that these amino acids are truly exceptional. Their redox activity under physiological conditions allows an amazing variety of posttranslational protein
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C2196-25MG | 04061832422947 |
| C2196-5MG | 04061832422954 |