Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

SMB01354

Sigma-Aldrich

Losartan carboxylic acid

≥95% (HPLC)

Synonym(s):

EXP3174, 2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid, E-3174, EXP 3174, EXP-3174

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C22H21ClN6O2
CAS Number:
124750-92-1
Molecular Weight:
436.89
MDL number:
MFCD00871928
UNSPSC Code:
12352106
NACRES:
NA.21

Quality Level

100

Assay

≥95% (HPLC)

form

solid

shipped in

wet ice

InChI

1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)

InChI key

ZEUXAIYYDDCIRX-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Losartan Carboxylic Acid (E-3174) is an active carboxylic acid metabolite of Losartan. Losartan Carboxylic Acid is a potent and selective angiotensin II receptor type 1 (AT1) antagonist.

Application

Metabolomics research

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H317,H360D,H362

Hazard Classifications

Lact. - Repr. 1B - Skin Sens. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SLCN0215

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A Gromotowicz-Poplawska et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 70(3) (2019-10-01)
The aim of the study was to evaluate the effect of an active metabolite of losartan - EXP3174 - on a performed venous thrombus in hypertensive rat. The contribution of coagulation and fibrinolytic systems as well as platelets in the
L L Chang et al.
Journal of medicinal chemistry, 36(17), 2558-2568 (1993-08-20)
A series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones was prepared via several synthetic routes and evaluated as AII receptor antagonists in vitro and in vivo. The preferred compounds contained a [2'-(5-tetrazolyl)biphenyl-4-yl]methyl side chain at N4 and an n-butyl group at C5. A number of
Eleni Karatza et al.
Basic & clinical pharmacology & toxicology, 126(3), 193-202 (2019-09-13)
Losartan presents multiple peaks in the concentration-time profile. This characteristic can be attributed to gastric emptying, which is known to significantly affect the disposition of highly soluble and permeable compounds. The aim of this study was to develop a population

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service