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481181

Sigma-Aldrich

Silver(I) sulfadiazine

98%

Synonym(s):

Silver sulfadiazine, Sulfadiazine silver

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About This Item

Empirical Formula (Hill Notation):
C10H9AgN4O2S
CAS Number:
Molecular Weight:
357.14
EC Number:
MDL number:
UNSPSC Code:
12352302
PubChem Substance ID:
NACRES:
NA.23

Assay

98%

form

powder

mp

285 °C (dec.) (lit.)

SMILES string

Nc1ccc(cc1)S(=O)(=O)N([Ag])c2ncccn2

InChI

1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1

InChI key

UEJSSZHHYBHCEL-UHFFFAOYSA-N

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Application

Silver(I) sulfadiazine (AgSD) is popularly used for treating second-degree burn wounds as it acts as an antimicrobial agent and prevents infections. Silver sulfadiazine-impregnated polyurethane (PU) foam, chitosan/chondroitin sulfate films may be used for wound dressing.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2


Certificates of Analysis (COA)

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Daniel J Ostlie et al.
Journal of pediatric surgery, 47(6), 1204-1207 (2012-06-19)
The 2 most commonly used topical agents for partial thickness burns are silver sulfadiazine (SSD) and collagenase ointment (CO). Silver sulfadiazine holds antibacterial properties, and eschar separation occurs naturally. Collagenase ointment is an enzyme that cleaves denatured collagen facilitating separation
Natural and synthetic polymers for wounds and burns dressing.
Mogosanu GD and Grumezescu AM
International Journal of Pharmaceutics, 463(2), 127-136 (2014)
Clinical experience with silver sulfadiazine, a new topical agent for control of pseudomonas infections in burns
Stanford, W, et al.
The Journal of Trauma and Acute Care Surgery, 9(5), 377-388 (1969)
Jason Wasiak et al.
The Cochrane database of systematic reviews, 3(3), CD002106-CD002106 (2013-04-02)
An acute burn wound is a complex and evolving injury. Extensive burns produce systemic consequences, in addition to local tissue damage. Treatment of partial thickness burn wounds is directed towards promoting healing and a wide variety of dressings are currently
Silver sulfadiazine-a new topical therapy for pseudomonas in burns: therapy of pseudomonas infection in burns
Fox CL
Archives of Surgery (Chicago, Ill. : 1960), 96(2), 184-188 (1968)

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