Yes, this item is soluble in the following solvents:
- Chloroform: 100 µg/ml
- DMSO: 200 µg/ml
- Ethanol: 100 µg/ml
Z4250
Zymosan A from Saccharomyces cerevisiae
for inducing inflamatory response
Synonym(s):
Yeast Cell Wall
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About This Item
Pricing and availability is not currently available.
Recommended Products
biological source
Saccharomyces cerevisiae
Quality Level
form
powder with small lumps
technique(s)
flow cytometry: suitable
tissue culture: suitable
color
off-white to light brown
storage temp.
2-8°C
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Application
- in flow cytometry[1]
- to study its effect on head kidney leukocytes from rainbow trout (Oncorhynchus mykiss)[2]
Zymosan A from Saccharomyces cerevisiae has been used:
- as a positive control to determine the activation of complement cascade[3]
- for respiratory burst (RB) assay[4]
- to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS)[5]
- a stimulating agent in Krebs-Ringer phosphate (KRP) medium[6]
- to induce thermal hyperalgesia in mice[7]
Biochem/physiol Actions
Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. Zymosan A, a 13 beta glucan contributes to the development of organic dust-induced respiratory disease.[8]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Is Z4250, Zymosan A from Saccharomyces cerevisiae, soluble in DMSO?
1 answer-
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How can Product Z4250, Zymosan be prepared for use in a properdin assay?
1 answer-
Information on preparation of zymosan for use in a properdin assay, which includes boiling zymosan suspensions, is described on the product information sheet (under Documents, above).
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How can I solubilize Zymosan, Product Z4250?
1 answer-
Solubility information can be found in the product information sheet (under Documents, above) on our website.
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Can Product Z4250, Zymosan suspension be autoclaved?
1 answer-
We have no information as to whether zymosan suspensions can be autoclaved. However, suspensions are stable to boiling conditions.
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What is the appearance of Product Z4250, Zymosan?
1 answer-
The product is a powder which is described on the specification sheet.
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What is the source of the Zymosan in Product Z4250?
1 answer-
This zymosan is prepared from single cell yeast.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the particle size of Product Z4250, Zymosan?
1 answer-
Sigma-Aldrich does not measure the particle size of zymosan. The average diameter of zymosan particles has been reported to be about 3 μm, as described on the product information sheet (under Documents, above), with the cited reference.
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