T4512

(±)-Taxifolin hydrate

≥90% (HPLC)

• Synonym(s): 3,3′,4′,5,7-Pentahydroxyflavanone hydrate, Dihydroquercetin hydrate
• Empirical Formula (Hill Notation): C₁₅H₁₂O₇ · xH₂O
• CAS Number: 24198-97-8
• Molecular Weight: 304.25 (anhydrous basis)
• MDL number: MFCD11044454
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278739
• NACRES: NA.25

Properties

• Assay: ≥90% (HPLC)
• form: powder
• solubility: DMSO: 20 mg/mL
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• SMILES string: O.O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c3ccc(O)c(O)c3
• InChI: 1S/C15H12O7.H2O/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6;/h1-5,14-19,21H;1H2/t14-,15+;/m0./s1
• InChI key: DNQPGSVMBPSRIR-LDXVYITESA-N
• Gene Information: mouse ... Hexa(15211)

Description

General description

Taxifolin or dihydroquercetin is a naturally occurring secondary metabolic compound found in many plants such as onions, milk thistle, Douglas fir bark, and French maritime pine bark.

Application

(±)-Taxifolin hydrate has been used to evaluate its effects when co-supplemented with trehalose to improve the quality of post-thawed ram semen. It may have been used as a reference standard to analyze the bioactive components of ethanolic extract of P. orientale (POE) using high-performance liquid chromatography (HPLC).

Biochem/physiol Actions

(±)-Taxifolin exerts various pharmacological properties that include anti-inflammatory, anti-cancer, antiviral, and antimicrobial activities. It displays neuroprotective, hepatoprotective effects, and it also protects against cardiovascular diseases.

Flavonoid, antioxidant. Inhibits lipogenesis in cancer cells, most likely by targeting fatty acid synthase activity.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves