SML3779

Methotrexate disodium salt

≥98% (HPLC)

• Synonym(s): Amethopterin sodium, N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt, Sodium methotrexate
• Empirical Formula (Hill Notation): C₂₀H₂₀N₈Na₂O₅
• CAS Number: 7413-34-5
• Molecular Weight: 498.40
• MDL number: MFCD00274560
• UNSPSC Code: 12352200
• NACRES: NA.21

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to brown
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: [Na].[Na].N([C@@H](CCC(=O)O)C(=O)O)C(=O)c1ccc(cc1)N(Cc2nc3c(nc(nc3N)N)nc2)C
• InChI key: HQRCOVOSZPGUCA-GXKRWWSZSA-N

Description

Biochem/physiol Actions

Folic acid antagonist that is used as an antineoplastic and antirheumatic drug

Methotrexate disodium salt is a potent is a folic acid antagonist that is used as an antineoplastic and antirheumatic drug. Methotrexate disodium salt is a potent inhibitor of dihydrofolate reductase.

Caution

Hygroscopic

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301,H315,H319,H341,H360D
• Precautionary Statements: P202 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable