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SML2231

Sigma-Aldrich

Erasin

≥98% (HPLC)

Synonym(s):

(E)-N′-((6-(tert-butyl)-4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide, Erlotinib-resistance antagonizing STAT3 inhibitor

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About This Item

Empirical Formula (Hill Notation):
C20H19N3O3
CAS Number:
2256056-21-8
Molecular Weight:
349.38
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1C(/C=N/NC(C2=CC=CN=C2)=O)=COC3=CC=C(C(C)(C)C)C=C31

InChI

1S/C20H19N3O3/c1-20(2,3)15-6-7-17-16(9-15)18(24)14(12-26-17)11-22-23-19(25)13-5-4-8-21-10-13/h4-12H,1-3H3,(H,23,25)/b22-11+

InChI key

JHUVYXUBEMYTNO-SSDVNMTOSA-N

Biochem/physiol Actions

Erasin (Erlotinib-resistance antagonizing STAT3 inhibitor) is a selective inhibitor of STAT3 with selectivity over STAT5 and STAT1 in cell-based assays. It was shown to increase the apoptotic rate of HCC-827 cells with acquired resistance against Erlotinib in addition to increasing the apoptotic rate of cultured NSCLC cells in a STAT3-dependent manner.
Selective inhibitor of STAT3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Christian Lis et al.
Scientific reports, 7(1), 17390-17390 (2017-12-14)
Inhibition of protein-protein interactions by small molecules offers tremendous opportunities for basic research and drug development. One of the fundamental challenges of this research field is the broad lack of available lead structures from nature. Here, we demonstrate that modifications

Questions

  1. I need a list of the percentage of ingredients in ERASI for products going to Canada. Required by health canada for personal care products.

    1 answer

    1. Please see section 3 and section 15 of the Safety Data Sheet:
      https://www.sigmaaldrich.com/sds/sigma/sml2231.

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