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species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type cell culture supernatant(s)
sample type plasma
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 1.96 ng/mL
standard curve range: 1.966-480 ng/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... LTF(4057)
General description
LTF (lactotransferrin) codes for a 80 kDa glycoprotein which is expressed in many tissues and organs such as mammary gland, uterus, kidney and brain and found in body fluids including tears, milk, vitreous humor and saliva. Lactotransferrin is considered pleiotropic. Lactotransferrin belongs to the transferrin family and is homologous in sequence and structure with iron binding protein. The LTF gene is mapped to human chromosome 3p21.31.
The LTF ELISA kit provides for the Quantitative measurement of Lactotransferrin in Cell Culture Supernatants, Plasma and Serum.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
Lactotransferrin regulates the immune and inflammatory responses. Lactotransferrin is also known to be involved in bone metabolism. It might play an important role in dental osseointegration implantation. Lactotransferrin is known for its antimicrobial anti-viral, anti-fungal, anti-parasitic, anti-inflammatory and antioxidant activity. Anti-angiogenic, anti-tumor effects of this protein proves that it is a tumor suppressor. Neuronal differentiation is also an important function of lactotransferrin.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Theresa J Ochoa et al.
Neonatology, 117(2), 167-174 (2020-02-14)
Lactoferrin (LF) is a protective protein present in milk with anti-infective and immune-modulating properties. The aim of this study was to determine the association of maternal LF intake and mother's own milk intake in the first 10 days of life
Katayi Mwila-Kazimbaya et al.
PloS one, 12(12), e0189351-e0189351 (2017-12-29)
Rotavirus vaccines have been introduced into national immunization programmes to mitigate morbidity and mortality associated rotavirus diarrhoea. Lower vaccine effectiveness has however been noted in low-middle income countries, but little is known about the role of maternal components found in
S Lanctôt et al.
Journal of dairy science, 100(3), 2269-2281 (2017-01-23)
The transition from lactation to the dry period in dairy cows is a period of high risk for acquiring new intramammary infections. This risk is reduced when the involution of the mammary gland is completed. Accordingly, approaches that speed up
B Ponchon et al.
Journal of dairy science, 100(10), 8496-8506 (2017-08-02)
The risk for a dairy cow to acquire new intramammary infections is high during the transition from lactation to the dry period, because of udder engorgement and altered immune functions. Once the gland is fully involuted, it becomes much more
Theresa J Ochoa et al.
The Journal of pediatrics, 219, 118-125 (2020-02-11)
To determine the effect of bovine lactoferrin on prevention of late-onset sepsis (LOS) and neurodevelopment delay. Randomized, double-blind, controlled trial in neonates with a birth weight of 500-2000 g in 3 neonatal units in Lima, Peru, comparing bovine lactoferrin 200 mg/kg/day
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