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P2918

Sigma-Aldrich

Human Serum

from platelet poor human plasma, sterile-filtered, (mycoplasma tested, virus tested)

Synonym(s):

human plasma, human sera, human serum

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About This Item

MDL number:
MFCD00165829
UNSPSC Code:
12352207
NACRES:
NA.71

biological source

human

sterility

sterile-filtered

origin

USA origin

technique(s)

cell culture | mammalian: suitable

impurities

(mycoplasma tested, virus tested)
≤10 EU/mL endotoxin

shipped in

dry ice

storage temp.

−20°C

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General description

The serum is the fluid part of the blood containing plasma without fibrinogen.

Application

Human Serum has been used:
  • in the preparation of human serum samples that mimic the COVID-19 patient samples for serological antibody testing
  • as a media supplement to differentiate human induced pluripotent stem cells (hiPS) to hiPS- brain microvascular endothelial cells (BMEC)
  • for culturing transgenic Plasmodium falciparum clone
  • for assessing the electrochemical response of recombinant P. falciparum parasite L-lactate dehydrogenase (LDH) in serum samples
  • in platelet-derived growth factor (PDGF) purification assays

Human serum from platelet poor plasma (PPP) is useful for studies of the effects of platelet lysates on the growth of cells such as articular chondrocytes and human skin fibroblasts. It has also been used in platelet derived growth factor (PDGF) purification assays.

Biochem/physiol Actions

Serum serves as a supplement to basal media formulations and conventional biomedical cell culture media. It acts as a source of trace nutrients, signaling molecules, growth factors, and hormones that induce proper cell growth in vitro. Human serum from platelet-poor plasma (PPP) is useful in the studies of the effects of platelet lysates on the growth of cells such as articular chondrocytes and human skin fibroblasts.

Analysis Note

Endotoxin tested

Other Notes

It is not unusual for a white precipitate to form following a freeze-thaw cycle for this human serum product.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Physiology, Blood Plasma null
Edward N O'Neill et al.
Comprehensive reviews in food science and food safety, 20(1), 686-709 (2020-12-17)
Innovation in cultivated meat development has been rapidly accelerating in recent years because it holds the potential to help attenuate issues facing production of dietary protein for a growing world population. There are technical obstacles still hindering large-scale commercialization of
Aver Hemben et al.
Talanta, 187, 321-329 (2018-06-02)
This paper describes the development of an affinity sensor for the detection of Plasmodium falciparum parasite lactate dehydrogenase (pLDH) as one of the biomarkers used for malaria detection. The gold sensor was functionalised with anti-pLDH after cleaning the electrode surface
Xiao Li et al.
Biosensors & bioelectronics, 177, 112672-112672 (2021-01-20)
Accurate, rapid, and low-cost molecular diagnostics is essential in managing outbreaks of infectious diseases, such as the pandemic of coronavirus disease 2019 (COVID-19). Accordingly, microfluidic paper-based analytical devices (μPADs) have emerged as promising diagnostic tools. Among the extensive efforts to
Marie Piantino et al.
Materials today. Bio, 14, 100232-100232 (2022-03-22)
The blood-brain barrier (BBB), a selective barrier formed by brain microvascular endothelial cells (BMEC), represents a major challenge for the efficient accumulation of pharmaceutical drugs into the brain. The receptor-mediated transcytosis (RMT) has recently gained increasing interest for pharmaceutical industry
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