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Key Documents

P1189

Sigma-Aldrich

Polymyxin B

liquid, suitable for cell culture, BioReagent

Synonym(s):

Aerosporin, PMB, PMX, Polymyxin, Polymyxin B

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About This Item

UNSPSC Code:
12352207
NACRES:
NA.76
Pricing and availability is not currently available.

Product Name

Polymyxin B ready made solution, Cell culture tested, 17 mg/mL in H2O

Quality Level

200

form

liquid

concentration

17 mg/mL in H2O

storage temp.

2-8°C

General description

Polymyxin B (PMB) is a cyclic cationic lipopeptide antibiotic originally produced by soil bacterium Bacillus polymyxa. Polymyxin B binds specifically to gram negative bacteria by interacting with the anionic lipopolysaccharide (LPS, or endotoxin). Polymyxin B interferes with the outer membrane normal function causing leakage and enhanced uptake of the antibiotic.

Polymyxin B has several applications:
  • It is used to neutralize LPS contamination in vitro and in vivo. Its neutralizing effect is dose-dependent. In vitro experiments showed that PMB inhibits a septic shock by endotoxin inactivation.
  • Cell cultures can be treated with PMB (100U/mL) to avoid early contaminations. PMB is considered a broad spectrum antibiotic and is used to treat infections caused by bacteria resistant to a combination of Penicillin and Streptomycin.
  • PMB is also used as negative and positive control in minimum microbicidal concentration (MIC) assay.

Working concentration:
The suggested concentration of PMB in cell culture mediums is 100U/mL. Therefore, it is recommended to dilute PMB ready made solution 1:1000.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000379924
0000327314
0000379924
0000327314
0000279069

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Questions

1–2 of 2 Questions  

  1. What is the molecular weight of the product?

    1 answer

    1. This product is made with Polymyxin B Sulfate, which has a molecular weight of 1385.61 g/mol.

      Helpful?

  2. What is the molecular weight of the product?

    1 answer

    1. This product is prepared using Polymyxin B Sulfate. The molecular weight of this compound is 1385.61 g/mol.

      Helpful?

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