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N6877

Sigma-Aldrich

L-Norleucine

≥98% (TLC)

Synonym(s):

(S)-(+)-2-Aminohexanoic acid, (S)-2-Aminocaproic acid

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About This Item

Linear Formula:
CH3(CH2)3CH(NH2)CO2H
CAS Number:
327-57-1
Molecular Weight:
131.17
Beilstein:
1721750
EC Number:
206-321-4
MDL number:
MFCD00064423
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24897796
NACRES:
NA.26

Assay

≥98% (TLC)

form

powder

color

white

mp

>300 °C (lit.)

application(s)

detection

SMILES string

CCCC[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-2-3-4-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)/t5-/m0/s1

InChI key

LRQKBLKVPFOOQJ-YFKPBYRVSA-N

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Application


  • l-norleucine on high glucose-induced insulin sensitivity and mitochondrial function in skeletal muscle cells. This study explores the beneficial effects of L-Norleucine on insulin sensitivity and mitochondrial function, underlining its potential in metabolic pathway research and its application in managing diabetes through targeted amino acid therapy (Ding et al., 2024).

Biochem/physiol Actions

L-Norleucine is a synthetic amino acid commonly used as an internal standard.

Other Notes

Non-essential amino acid.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The conversion of the cellular prion protein (PrP(C)) into its disease-associated form (PrP(Sc)) involves a major conformational change and the accumulation of sulfoxidized methionines. Computational and synthetic approaches have shown that this change in the polarity of M206 and M213
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Journal of agricultural and food chemistry, 58(4), 2543-2547 (2010-01-29)
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