J2000

Juvenile hormone III

≥65%, liquid, non-sterile

• Synonym(s): Methyl farnesoate, 10,11-epoxide, C₁₆-Juvenile Hormone, JH-III, Manduca hormone, trans,trans-10,11-Epoxy-3,7,11-trimethyl-2,6-dodecadienic acid methyl ester
• Empirical Formula (Hill Notation): C₁₆H₂₆O₃
• CAS Number: 24198-95-6
• Molecular Weight: 266.38
• UNSPSC Code: 51111800
• NACRES: NA.32
• PubChem Substance ID: 24896191
• EC Number: 246-072-9
• Beilstein/REAXYS Number: 1316317
• MDL number: MFCD00135990
• Biological source: synthetic (organic)
• Form: liquid
• Assay: ≥65% (HPLC)

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• sterility: non-sterile
• assay: ≥65% (HPLC)
• form: liquid
• concentration: ≥65%
• technique(s): activity assay: suitable
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: COC(=O)\C=C(/C)CC\C=C(/C)CC[C@H]1OC1(C)C
• InChI: 1S/C16H26O3/c1-12(9-10-14-16(3,4)19-14)7-6-8-13(2)11-15(17)18-5/h7,11,14H,6,8-10H2,1-5H3/b12-7+,13-11+
• InChI key: QVJMXSGZTCGLHZ-ZPLWXOMKSA-N

Description

General description

Research Area: Cell Signaling

Juvenile hormone III (JH III) is the most prevalent juvenile hormone (JH) found in insects.

Application

Juvenile hormone III has been used to:

• study the effect of juvenile hormone on mictic (sexual) female production of the rotifer Brachionus plicatilis Muller
• study the effect of juvenile hormone on head GB19811 (putative Takeout/juvenile hormone binding protein) mRNA levels in adult honeybees
• study the effect of juvenile hormone on gonadotropic and physiological functions in bumblebee Bombus terrestris

Biochem/physiol Actions

Controls the larval metamorphosis of insects, including the retention of juvenile characteristics.

JHBPs (JH-binding proteins) protect JH (juvenile hormone) from JH esterase- and epoxide hydrolase-mediated degradation. They also help in delivering JH to target tissues.Juvenile hormones(JHs) are a group of acyclic sesquiterpenoids, and in some insect lineages, the farnesol backbone of these compounds undergoes chemical modification to produce a homologous series of hormones. JH is essential for insect development and reproduction in every aspect. It plays a key role in metamorphosis and caste determination in social insects. It modulates behavior, polyphenism, larval and adult diapause, and ovarian development. The sesquiterpenoid backbone of juvenile hormone III (JH III) is biosynthesized through the classical mevalonate (MVA) pathway in cockroaches.

Safety Information

• hcodes: H413
• Hazard Classifications: Aquatic Chronic 4
• Storage Class: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)