B150

BQ-123

≥99%, sodium salt, lyophilized powder

• Synonym(s): BQ123, Cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)
• Empirical Formula (Hill Notation): C₃₁H₄₁N₆O₇ Na
• CAS Number: 136553-81-6
• Molecular Weight: 632.68
• MDL number: MFCD00133204
• UNSPSC Code: 12352204
• PubChem Substance ID: 24891595
• NACRES: NA.32

Properties

• Quality Level: 200
• Assay: ≥99%
• form: lyophilized powder
• storage temp.: −20°C
• SMILES string: [H][C@@]12CCCN1C(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC2=O)C(C)C
• InChI: 1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1
• InChI key: VYCMAAOURFJIHD-PJNXIOHISA-N
• Gene Information: human ... EDNRA(1909) , EDNRB(1910) ; rat ... Ednra(24326) , Ednrb(50672)

Description

Amino Acid Sequence

cyclo-Asp-Pro-Val-Leu-Trp

Application

BQ-123 has been used as a selective endothelin-A receptor antagonist to study its effects on tumor necrosis factor α (TNFα)-induced human airway smooth muscle cells (HASMCs) proliferation. It is also used as endothelin-A receptor antagonist to study its effects on TNFα-induced granulocyte–macrophage colony-stimulating factor (GM-CSF) expression.

Biochem/physiol Actions

BQ-123 is an endothelin(Et) receptor antagonist and is exquisite for endothelin A (ETA) receptor. It is a cyclic pentapeptide.

Selective ET_A endothelin receptor antagonist.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves