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T76201

Sigma-Aldrich

Trimethylene oxide

97%

Synonym(s):

1,3-Epoxypropane, 1,3-Propylene oxide, Cyclooxabutane, Oxacyclobutane, Oxetane

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About This Item

Empirical Formula (Hill Notation):
C3H6O
CAS Number:
503-30-0
Molecular Weight:
58.08
Beilstein:
102382
EC Number:
207-964-3
MDL number:
MFCD00005167
UNSPSC Code:
12352100
PubChem Substance ID:
24900463
NACRES:
NA.22

vapor pressure

5.09 psi ( 20 °C)

Assay

97%

refractive index

n20/D 1.388-1.396
n20/D 1.392 (lit.)

bp

50 °C (lit.)

density

0.893 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

C1COC1

InChI

1S/C3H6O/c1-2-4-3-1/h1-3H2

InChI key

AHHWIHXENZJRFG-UHFFFAOYSA-N

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Application

  • Trimethylene oxide is a strained cyclic ether which can be used to replace carbonyl / gem-dimethyl groups during molecular modelling of bioactive molecules.
  • It can be incorporated in various bioactive molecule and drug substances for its improved physicochemical properties, via novel C-H activation methods.
  • Trimethylene oxide can also be used in the synthesis of poly(trimethylene oxide) and related polymer electrolytes.

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225,H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

-4.0 °F - closed cup

Flash Point(C)

-20 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Role of polar side chains in Li+ coordination and transport properties of polyoxetane-based polymer electrolytes.
Sai R, et al.
Physical Chemistry Chemical Physics, 19(7), 5185-5194 (2017)
Synthesis and characterization of high molecular weight poly (trimethylene oxide).
Qureshi MY and Ochel M
Eur. Polymer J., 32(6), 691-693 (1996)
Oxetanes: recent advances in synthesis, reactivity, and medicinal chemistry.
Bull JA, et al.
Chemical Reviews, 116(19), 12150-12233 (2016)
Cross-linked poly (oxetane) matrix for polymer electrolyte containing lithium ions.
Tsutsumi H, et al.
Solid State Ionics, 262, 761-764 (2014)
Dong-Dong Wu et al.
Organic & biomolecular chemistry, 10(18), 3626-3635 (2012-04-13)
Photoinduced reactions of isatin and N-methyl-1,3,4-isoquinolinetrione with bicycloalkylidenes such as bicyclopropylidene, cyclopropylidenecyclobutane, cyclopropylidenecyclohexane and bicyclohexylidene were investigated. The reactions gave spirooxetanes as the major products derived from the [2 + 2] photocycloaddition pathway via 1,4-biradical recombination. Unusual products including the
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