Skip to Content
Merck
All Photos(1)

Documents

V8639

Sigma-Aldrich

VO-OHpic trihydrate

≥98% (HPLC), solid

Synonym(s):

(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C12H9N2O8V · H · 3H2O
CAS Number:
476310-60-8
Molecular Weight:
415.20
UNSPSC Code:
41121801
PubChem Substance ID:
329829435
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

color

gray

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

SMILES string

O.O.O.O.Oc1cccnc1C(=O)O[VH]2(=O)OC(=O)c3cccnc3O2

InChI

1S/2C6H5NO3.4H2O.O.V.H/c2*8-4-2-1-3-7-5(4)6(9)10;;;;;;;/h2*1-3,8H,(H,9,10);4*1H2;;;/q;;;;;;;+3;/p-3

InChI key

QVBVJWFAUFEGMT-UHFFFAOYSA-K

General description

VO-OHpic is a vanadium complex. VO-OHpic might act as a possible pro-senescence anti-cancer drug for treating cancers with reduced phosphatase and tensin homolog (PTEN) expression. It blocks cell viability, cell proliferation, colony formation and induced senescence-associated β-galactosidase activity in Hep3B cells.

Application

VO-OHpic trihydrate has been used in studying the role of phosphatase and tensin homolog (PTEN) in polycomb repressive complex 2 (PRC2)-mediated apoptosis. It also has been used as a PTEN inhibitor to study the neuroprotective effect of melatonin in amyloid beta (Aβ)-induced neurotoxicity via PTEN pathway.

Biochem/physiol Actions

VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Melatonin protects against Abeta-induced neurotoxicity in primary neurons via miR-132/PTEN/AKT/FOXO3a pathway
Zhao Y, et al.
Biofactors (2018)
Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells
Benoit YD, et al.
Experimental Cell Research, 319(10), 1463-1470 (2013)
A PTEN inhibitor displays preclinical activity against hepatocarcinoma cells
Augello G, et al.
Cell Cycle, 15(4), 573-583 (2016)
Erika Rosivatz et al.
ACS chemical biology, 1(12), 780-790 (2007-01-24)
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling. The loss or impairment of PTEN results in an antidiabetic impact, which led to the suggestion that PTEN could be an
Ying-Zi Liu et al.
International journal of oncology, 45(1), 104-112 (2014-04-24)
Colon cancer is one of the most common malignancies and the treatments for colon cancer have been developed substantially in the last decades, but there is still a great clinical need to explore new treatment regimens due to the undesirable
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service