SAB4500003

Anti-BCL-2 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, BCL2
• MDL number: MFCD00239644
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 26 kDa
• species reactivity: rat, mouse, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:10000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P10415
• UniProt accession no.: P10415
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... BCL2(596)

Description

General description

B-cell lymphoma 2 (BCL-2) is an integral inner mitochondrial membrane protein that acts as an antiapoptotic protein. It is a target gene of nuclear factor kappa B (NF-kB). The gene encoding BCL-2 is localized on human chromosome 18q21.

Immunogen

The antiserum was produced against synthesized peptide derived from human BCL-2.

Immunogen Range: 46-95

Application

Anti-BCL-2 antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

BCL2 is an apoptosis regulator that is expressed in sub-cellular components such as the mitochondria and nucleus. While mitochondrial BCL2 inhibits apoptosis, BCL2 present in the nucleus may activate cell death. BCL2 may also regulate autophagy during starvation . Anti-BCL-2 antibodies are specific for endogenous levels of total BCL-2 protein in rats, humans and mice.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable