l-norleucine on high glucose-induced insulin sensitivity and mitochondrial function in skeletal muscle cells. This study explores the beneficial effects of L-Norleucine on insulin sensitivity and mitochondrial function, underlining its potential in metabolic pathway research and its application in managing diabetes through targeted amino acid therapy (Ding et al., 2024).
Biochem/physiol Actions
L-Norleucine is a synthetic amino acid commonly used as an internal standard.
Until now, there has been a lack of analytical methods that can reliably verify the authenticity of organically grown plants and derived organic food products. In this study, stable isotope ratio analysis of hydrogen (H, δ2H), carbon (C, δ13C), nitrogen
The Journal of organic chemistry, 77(12), 5423-5428 (2012-05-24)
A short, concise synthesis of enantiopure, side chain-modified α-amino acids such as 4-oxo-L-norvaline, 6-oxo-L-homonorleucine, and 5-cis-alkyl prolines is described. Knoevenagel condensation of l-aminocarboxylate-derived β-ketoesters with aldehydes followed by reductive decarboxylation results in unnatural α-amino acids in good yield. A fluorescent
Australian veterinary journal, 89(3), 95-100 (2011-02-18)
Four dogs presented with clinical signs of severe hepatic disease after consuming a commercial camel meat diet. Laboratory investigation revealed evidence of severe liver disease, including markedly increased serum alanine aminotransferase (ALT) activity and total bilirubin concentration, and prolonged clotting
The journal of physical chemistry. B, 114(36), 11820-11826 (2010-08-24)
Following the studies of urea denaturation of β-hairpins using molecular dynamics, in this paper, molecular dynamics simulations of two peptides, a 35 residue three helix bundle villin headpiece protein HP-35 and its doubly norleucine-substituent mutant (Lys24Nle/Lys29Nle) HP-35 NleNle, were undertaken
With an increasing worldwide demand for animal protein, insects are becoming a promising sustainable option for meat protein replacement. However, reported protein contents of insects are often overestimated when calculated as "crude protein" = 6.25 × nitrogen content (N), compared
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