L2515

Lipoteichoic acid from Staphylococcus aureus

bacterial cell wall polymer

• CAS Number: 56411-57-5
• MDL number: MFCD00131526
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• biological source: Staphylococcus aureus
• Quality Level: 200
• form: lyophilized powder
• functional group: phospholipid
• lipid type: polymerizable lipids
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

Lipoteichoic acid (LTA) is a linear polymer of phosphodiester-linked glycerol phosphate covalently bound to a lipid. The C2 position on the glycerol-phosphate is usually glycosylated or D-alanylated. LTA is amphipathic due to the presence of the negatively charged backbone of glycerol phosphate and the hydrophobic lipid. The lipid portion is bound hydrophobically to the cell membrane, whereas the polyglycerol phosphate portion extends into the cell wall.

Lipoteichoic acid (LTA) is a teichoic acid attached to a lipid abundant on Gram-positive bacteria cell wall. LTA is a pathogen-associated molecular-patterns (PAMP) recognized by Toll-like receptor 2 (TLR2), This recognition leads to the activation of NF-kB.

Application

Lipoteichoic acid from Staphylococcus aureus has been used:

• to investigate the binding properties of SpHyastatin to lipopolysaccharides and lipoteichoic acid using enzyme-linked immunosorbent assay (ELISA)
• to measure the interleukin (IL-6) produced in splenocytes using a sandwich ELISA
• as a toll-like receptor 2/6 (TLR2/6) agonist to explore its potential to induce tumoricidal M1 macrophage phenotype

Biochem/physiol Actions

Lipoteichoic acid (LTA) is a complex component of cell walls of Gram-positive bacteria that are involved in a wide range of cell processes such as the stimulation of immune responses and cell signaling pathways. LTA differs between species of gram-positive bacteria. Lipoteichoic acid from Streptococcus aureus may be used to compare its structure, immunogenicity and functions versus other bacterial LTAs.

Lipoteichoic acid (LTA) is a complex component of the cell walls of Gram-positive bacteria that are implicated in a wide range of cellular processes such as the stimulation of immune responses and cell signaling pathways. LTA differs between species of Gram-positive bacteria. Lipoteichoic acid from Streptococcus aureus may be used to compare its structure, immunogenicity, and functions versus other bacterial LTAs.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves