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Key Documents

A3253

Sigma-Aldrich

Ala-Pro hydrate

≥98% (TLC), suitable for ligand binding assays

Synonym(s):

L-Alanyl-L-proline hydrate

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About This Item

Empirical Formula (Hill Notation):
C8H14N2O3 · xH2O
CAS Number:
Molecular Weight:
186.21 (anhydrous basis)
Beilstein:
3546017
EC Number:
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.26

Product Name

Ala-Pro hydrate,

Assay

≥98% (TLC)

Quality Level

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

O.C[C@H](N)C(=O)N1CCC[C@H]1C(O)=O

InChI

1S/C8H14N2O3.H2O/c1-5(9)7(11)10-4-2-3-6(10)8(12)13;/h5-6H,2-4,9H2,1H3,(H,12,13);1H2/t5-,6-;/m0./s1

InChI key

SSUWZOPYGFOQJA-GEMLJDPKSA-N

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Biochem/physiol Actions

Alanyl dipeptides such as ala-leu, ala-lys, ala-gly, ala-pro, ala-tyr and ala-phe may be used in physicochemical studies or to evaluate dipeptide separation technologies. Alanyl dipeptides may also be used for studying cell uptake mechanisms, dipeptide metabolism or cell growth supplementation benefits.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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S Capasso et al.
Peptides, 19(2), 389-391 (1998-03-11)
Diketopiperazine formation from the N-terminal residues of a peptide chain is accelerated by aprotic dipolar protophobic solvents and catalyzed in organic solvents by alkylammonium carboxylate salts. The t1/2 for the first-order reaction of H-Ala-Pro-NH2 x TFA falls from 20 d
J Butterworth et al.
Journal of inherited metabolic disease, 8(4), 193-197 (1985-01-01)
Two forms of prolidase can be separated for all the human cells and tissues examined by DEAE-cellulose column chromatography or batch methods. Serum had a very low prolidase activity eluting as a single peak prior to tissue peak I prolidase.
H Ke et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(8), 3324-3328 (1993-04-15)
Cyclophilin is a binding protein for the immunosuppressive drug cyclosporin A and is also an enzyme with peptidyl-prolyl cis-trans isomerase activity. The crystal structure of cyclophilin A complexed with the substrate Ala-Pro has been determined and refined to an R
Young-Ok Kim et al.
The Journal of general and applied microbiology, 55(5), 345-350 (2009-11-27)
Citrobacter braakii produced an intracellular acid glucose phosphatase (AgpC) which was purified 986 fold to homogeneity with the specific activity of 286 units/mg. AgpC hydrolyzed a wide variety of phosphorylated compounds with high activity for glucose-1-phosphate and glucose-6-phosphate. The optimum
Byung Jin Byun et al.
The journal of physical chemistry. B, 114(44), 14077-14086 (2010-10-19)
Conformational preferences and prolyl cis-trans isomerizations of the X-Pro motifs (Ac-X-Pro-NHMe, X = Ala and Aib) are explored using the meta-hybrid functional M06-2X and the double-hybrid functional B2PLYP-D with empirical dispersion corrections in the gas phase and in water, where

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