63175

4-Maleimidobutyric acid N-hydroxysuccinimide ester

≥98.0% (HPLC)

• Synonym(s): 4-Maleimidobutyric acid N-succinimidyl ester, N-(γ-Maleimidobutyryloxy)succinimide, N-Succinimidyl 4-maleimidobutyrate, GMBS
• Empirical Formula (Hill Notation): C₁₂H₁₂N₂O₆
• CAS Number: 80307-12-6
• Molecular Weight: 280.23
• Beilstein: 6427689
• MDL number: MFCD00036817
• UNSPSC Code: 12352106
• PubChem Substance ID: 329759802
• NACRES: NA.25

Properties

• Quality Level: 100
• Assay: ≥98.0% (HPLC)
• reaction suitability: reagent type: linker
• mp: 123-129 °C
• functional group: NHS ester
• storage temp.: 2-8°C
• SMILES string: O=C1N(CCCC(ON2C(CCC2=O)=O)=O)C(C=C1)=O
• InChI: 1S/C12H12N2O6/c15-8-3-4-9(16)13(8)7-1-2-12(19)20-14-10(17)5-6-11(14)18/h3-4H,1-2,5-7H2
• InChI key: PVGATNRYUYNBHO-UHFFFAOYSA-N

Description

Application

A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Provides a 7-atom linker.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves